MIEDGE
The international joint project Mi*EDGE, in which a total of five partners from France, Luxembourg, Italy and Germany are involved, deals with glioblastoma, a malignant brain tumour. Treatment for this previously incurable cancer currently consists of partial neurosurgical removal of the tumour tissue, followed by radiotherapy and oral chemotherapy. In almost all patients, the tumour recurs despite such aggressive initial treatment. The biological behaviour of the glioblastoma cells at the edge of the tumour is particularly important for the clinical course and quality of life of patients. The more precisely this can be predicted, the greater the success of the therapy.
This is where Mi*EDGE comes in: As part of the international network, existing mathematical models that predict the behaviour of these tumour cells are to be expanded. The plan is to combine clinical image data from magnetic resonance imaging with comprehensive tissue analyses of individual patients and analyse them using artificial intelligence. The results are to be integrated into existing mathematical models that are used to analyse tumour cells. Supplemented with findings on cell interactions between macrophages and glioblastoma cells, the aim is to simulate and estimate the behaviour of the tumour cells in the peripheral area. The planned integration of preoperative neuroimaging into the mathematical models is of particular importance.
The newly acquired knowledge will make a significant contribution to improving future treatment decisions and optimising the timing of second surgical interventions, radiotherapy and chemotherapy.
Partners
- Hannover Medical School, Deutschland
- University of Strasbourq, Frankreich
- Centre of Neuropatholoqy, Luxemburg
- Instituto Clinico Humanitas, Italien
Duration
07/2020 - 05/2024
Funding
