Metabolic and Endocrine Drivers of Infection Susceptibility

Infectious and metabolic diseases rank among the leading causes of mortality worldwide. Strong scientific evidence highlights the profound and bidirectional interactions between infectious and metabolic diseases that have significant impact on disease progression, severity, treatment response, and overall quality of life. The global impact of this interplay became particularly evident during the COVID-19 pandemic, which—when combined with the ongoing non-communicable pandemic of metabolic disorders—has substantially increased morbidity and mortality across populations. It is beyond doubt that a new generation of scientists and physicians will have to tackle the challenge of these two closely interrelated health threats.

This IRTG is dedicated to exploring two fundamental aspects of the interplay between metabolic and infectious diseases The first “Pathogens targeting the endocrine system” will investigate the systemic and tissue-specific effects of viral and bacterial infection on endocrine and metabolic function. The second “Endocrine and metabolic regulation of infection” will focus on how endocrine/metabolic mechanisms and their impairment may increase infection susceptibility and severity and whether endocrine/metabolic interventions can restore response to infection.

With the support of the German Research Foundation (DFG), IRTG-MEDIS has been established as a collaborative effort between Technische Universität Dresden (TUD), ETH Zurich (ETH), and the University of Zurich (UZH). Our PhD and MD students from across the world, selected based on the highest academic standards, receive cutting-edge training in an interdisciplinary and international research environment. Through this program, we foster a deep understanding that tackling these critical health challenges requires cross-border collaboration and teamwork. Our ultimate goal is to train the next generation of scientists and physicians who will drive innovative solutions for the benefit of patients and society.