Roeder Lab: Medical systems biology and biometry

The research focus of the Roeder Lab comprises topics from the areas: systems biology / medicine (in particular mathematical modelling and computer simulation),  medical biometry / statistics, as well as data integration and study design. A major objective of the research activities in the group is the combination of basic research strategies with clinical applications. This aim leads to a high degree of interdisciplinary, which is reflected by the different research foci listed above. The overarching research theme of the group is the use of theoretical methods and mathematical / statistical modelling approaches to foster evidence-based clinical decision-making and the efficient design and analysis of experimental studies and clinical trials ("model-based medical research“).

Research areas

Systems biology, systems medicine, mathematical modelling

This research focus deals with the development and the application of mathematical models in different areas of the life sciences. Beside basic research questions in biology (e.g. clonal competition at the level of stem cells, stem cell – niche interactions or cell migration), we specifically address topics with an explicit clinical relation (e.g. disease and treatment models of different leukemia types and other malignancies). It is our objective to understand and predict the mechanisms that underlie dynamic physiological and pathophysiological processes by the application of analytic approaches as well as by computer simulation.

Medical Biometry and Bioinformatics

This research area focuses on the development and application of innovative data analysis methods, including the fields of experimental and clinical trial design. Beside methods from “classical” biometry / statistics, we are also working on machine learning and bioinformatics methods including techniques for the integrative analysis of molecular high-throughput data and for the analysis of imaging data.
The scientific focus is complemented by services, which are provided in the context of project-related counselling as well as training offers. 

Medical Informatics

Modern diagnostic procedures and/or measurement techniques provide ever-increasing amounts of data (e.g. individual genomic profiles, multi-modal image data, etc.). To use the information contained in these data for the more efficient diagnostics and/or the development of improved therapeutic strategies, a large number of steps are necessary. Beside data safety/integrity, also efficient data storage and data management solutions as well as the integration of different data types are in the focus of current research activities. In our group, we are specifically concerned with the development and implementation of integrated data storage and analysis methods, which allow to extract quantitative information out of clinical trials, to analyse them, and to use the generated knowledge directly for the design of new clinical trials.

Projects

current projects:

finished projects (selection):

  • Analysis of cell migration patterns in the zebrafish embryo (TU Dresden)
  • CHOICE — Characterization of the osteo-hematopoietic niche during malignant evolution (DKTK)
  • Control-T — Mathematical modeling of homeostasis and oncogenesis in mature T cells (DFG, Research group FOR1961)
  • ERANET-PLL — Implementation of (epi)genetic and metabolic networks in the targeting of T-cell prolymphocytic leukemia (BMBF, EU -  Era-Net / TRANSCAN-2)
  • HaematoOPT — Model-based optimization and individualization of treatment strategies in hematology (BMBF, e:Med Demonstratoren)
  • Mathematical Modelling of Stem Cell / Niche Interactions (TU Dresden)

  • Machine Learning-based tumour classification in mass-spectrometry data (TU Dresden, NCT)

  • MEDiC —Modellstudiengang Medizin (Bund, Freistaat Sachsen)

  • Network-based identification of candidate genes in oligodendroglioma (TU Dresden, NCT)

  • prediCt — Mathematical modelling of TKI effects and immune response to predict patient-specific treatment dynamics in CML (BMBF, EU - ERACSysMed)

  • Statistical modelling of early engraftment kinetics after stem cell transplantation in AML (TU Dresden)

  • SyTASC — Systems-based Therapy of AML Stem Cells (Deutsche Krebshilfe e.V.)

Group leader

Bild Prof. Dr. rer. med. Ingo Röder © P.Benjamin/NCTDD

Group leader

Name

Mr Prof. Dr. rer. med. Ingo Röder

Institute Director

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Members of the research group

Gerdes, Sebastian (research fellow)
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Research fellow

Name

Mr Dr. med. Sebastian Gerdes

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Klimova, Anna (research fellow)
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Research fellow (external: NCT)

Name

Ms Dr. Anna Klimova

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Kuhn, Matthias (research fellow)
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Research fellow

Name

Mr Matthias Kuhn M.Sc.

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Mauer, René (research fellow)
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Research fellow

Name

Mr Dr. rer. nat. René Mauer

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Mueller, Gabriele (research fellow)
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Research fellow

Name

Ms Dipl.-Ing. Gabriele Müller

ZEGV/IMB

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Pelz, Anne (application programmer & web developer)
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application programmer & web developer

Name

Ms Anne Pelz M.Sc.

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Rank, Michael (research fellow)
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Research fellow

Name

Mr Michael Rank M.Sc.

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Schubert, Konrad (research fellow)
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Research fellow

Name

Mr Dipl.-Math. Konrad Schubert

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Schuster, Silvio (System administration & data management)

System administration & data management

Name

Mr Dipl.-Inf. (FH) Silvio Schuster

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+49 351 458-5799

Uschner, Friedemann (research fellow)
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Research fellow

Name

Mr Dr. rer. nat. Friedemann Uschner

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Zerjatke, Thomas (Ph.D. student)
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Ph.D. student

Name

Mr Dipl.-Biomath. Thomas Zerjatke

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Students (MD/ Ph.D. students, student assistants)

Breidenstein, Jonas (MD student, research assistant)

MD student, research assistant

Name

Mr Jonas Breidenstein

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Nugraha, Osman Abhimata (Student assistant)
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Student assistant

Name

Mr Osman Abhimata Nugraha B.Eng.

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Schwager, Leonhard (MD student)
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MD student

Name

Mr Leonhard Schwager

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Seurig, Sebastian (MD student, student assistant)
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MD student

Name

Mr Sebastian Seurig

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Former staff members

de Back, Walter (research fellow)
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Research fellow (external: ZIH)

Name

Mr Dr. Walter de Back

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Diebner, Hans H. (research fellow)
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Research fellow

Name

Mr Dr. rer. nat. Hans Diebner

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Gaspari, Erika (ERASMUS student)

ERASMUS student

Name

Ms Erika Gaspari B.Sc.

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Griehl, Max (student researcher)
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Student assistant

Name

Mr Max Griehl

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Herberg, Maria (Ph.D. student Dr. rer. med.)
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Ph.D. student

Name

Ms Dr. rer. med. Maria Herberg

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Hoffmann, Helene (Ph.D. student)
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Ph.D. student

Name

Ms Helene Hoffmann M.Sc.

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Hoffmann, Katja (Database programmer)
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Research fellow

Name

Ms Katja Hoffmann

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Liebscher, Hendrik (MD student)
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MD student

Name

Mr Hendrik Liebscher

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Mikhaylenko, Nathan (research fellow)

Research fellow

Name

Mr Dr. rer. nat. Nathan Mikhaylenko

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Ortiz Cervantes, Adrian (Ph.D. student)

Ph.D. student

Name

Mr Adrian Ortiz Cervantes M.Sc.

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Pahlavan, Pirasteh (research fellow)
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Research fellow (external: NCT)

Name

Ms Dr. rer. nat. Pirasteh Pahlavan

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Pricop-Jeckstadt, Mihaela (research fellow)
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Research fellow

Name

Ms Dr. rer. nat. Mihaela Pricop-Jeckstadt

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Range, Ursula (research fellow)
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Research fellow

Name

Ms Dipl.-Math. Ursula Range

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Stange, Thoralf (research fellow)
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Research fellow (NCT)

Name

Mr Dipl.-Inf. Thoralf Stange

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Thierbach, Konstantin (Ph.D. student)
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Ph.D. student

Name

Mr Dipl.-Inf. Konstantin Thierbach

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Weber, Anke (research fellow)
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Research fellow

Name

Ms Dr. med. Anke Weber

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Publications of the lab

Note: The following content is from https://imb.medizin.tu-dresden.de.

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Anne Pelz
Last modified: Feb 22, 2024