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Projektleiter:
Prof. Dr. Michael Gelinsky
Koordinatorin:
Dr. Anna Tampieri (ISTEC, Faenza)
Laufzeit:
09/2010 - 08/2014
Projektbeschreibung:
OPHIS aims to develop new engineered biomaterials for the repair and regeneration of both the os-teo-chondral region and the vertebral body in patients affected by severe osteoarthritis (OA) and osteoporosis (OP).
These biomaterials will be based on the unique combination of biopolymeric scaffolds with a macroporous architecture presenting:
(i) nanostructured functionalisation able to mimic the extracellular matrices (ECM) of either bone or cartilage together with
(ii) chemical and biochemical cues able to direct, control and preserve the phenotypes of both osteoblasts andchondrocytes in their respective histological compartments.
These novel, nano-structured, bio-functional biomaterials will be obtained by engineering 3D-graded composite scaffolds through either blending or interpenetrating polymer networks. These methods will lead to tissue substitutes able to promote regeneration of
(i) trabecular bone
(ii) mineralised cartilage
(iii) hyaline cartilage.
These bioactive and biomimetic substitutes will be designed to be implanted under minimally invasive surgery. These will take the form of malleable constructs in the case of OA lesions and injectable paste formulations in the case of vertebroplasty. These features will be achieved using hydrogels and cement formulations capable of maintaining a critical porosity upon implantation or injection. The critical porosity will be optimised and preserved by the use of porogens and biopolymers with tuneable viscosity. These formulations will also improve the accuracy of the delivery to the targeted anatomical sites.
Projektbearbeiter:
Dr.-Ing. Florian Despang
Kooperationspartner:
Institute of Science and Technology for Ceramics (ISTEC), Faenza, Italien
Friedrich-Schiller-Universität, Jena
University of Brighton, UK
Universitätsklinikum Basel, Schweiz
Finceramica Faenza, Italy
University of Bologna, Rizzoli Orthopaedic Institute, Italien
Laboratoire d’Evaluation des Matériaux Implantables (LEMI), Bordeaux, Frankreich
Gemelli University Hospital, Catholic University of Rome, Italien