Details zur Lehrveranstaltung
| Introduction to Biophysics | |
| Modul: | Phy-Ma-Vert: Physikalische Vertiefung |
| Vorlesungssprache | Englisch |
| Inhalt der Lehrveranstaltung: | This lecture is an introduction to the physics of biological systems at the molecular and cellular level. In addition to providing all the basic information on this topic, the emphasis is on the physical design principles that living systems use to accomplish various cellular processes, enabling them to sense and react to their environment. A set of case studies aims to demonstrate how physicists' experience of the complex systems can complement experimental investigations by biologists to explain how living systems work, and why biology is the way it is. • Cells: What's in a cell? Component molecules. Cellular processes. Significance of Brownian motion, noise and stochasticity. • Information and Regulation: DNA replication. RNA, transcription and translation. Promotors, repressors and operons, DNA topology. Gene regulatory networks. • Energy: Chemiosmotic theory. Membrane potential, Nernst relation, ion channels and pumps. Metabolism and the synthesis of ATP. • Structural elements: The cytoskeleton: mictrotubles, actin filaments, networks and gels. • Cell movements and locomotion. Mechanosensing. • Molecular machines: Motor proteins and isothermal ratchets. Mechanochemistry and the Kramers equation. Muscle contraction. Processive motors. Rotary motors. • Sensory cells: Hair cells in the ear. Active signal detection and cochlear mechanics. Phototransduction in the retina. • Nerve impulses: Axons and the action potential. Hodgkin-Huxley model. Spiking and bursting. |
| Datensatz aktualisiert | |
| Umfang: | Vorlesung: 2 Stunden/Woche |
| Zeit/Ort: | MI(5) REC/B214 |
| Hörerkreis: | Vertiefung Bachelor (PV) und Master (alle) |
| Vertiefungsgebiet: | |
| Vorkenntnisse: | Basic knowledge in physics, maths and chemistry and a keen interest in biology | Nachweis: | Problemset |
| Einschreibung: | N/A |
| Web-Referenz: | http://www.biotec.tu-dresden.de/research/guck/ |
| The lecture will be held jointly by Prof. Jochen Guck (BIOTEC) and Dr. Moritz Kreysing (MPI-CBG). | |