Picture of neurons © Natalia Rodriguez-Muela

Rodriguez-Muela Group

Motor neuron diseases are a group of disorders in which motor neurons (MNs) of the spinal cord and/or the motor cortex are the primary cell type affected where this perplexing feature can also be observed. Using a variety of approaches ranging from cellular biology techniques and live imaging to genome editing and single cell genomics, and utilizing hiPSC together with transgenic animal models, we investigate the molecular mechanisms underlying such selective MN death. We devote a special focus at exploring the molecular basis of proteostasis failure -major causative event in neurodegeneration-, and at examining the contribution of cell autonomous and non-cell autonomous factors to the selective MN loss.

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Picture of neurons © Natalia Rodriguez-Muela

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Portrait of Dr. Natalia Rodriguez-Muela © CRTD/Friederike Braun

Group Leader


Dr. Natalia Rodriguez-Muela