GHGA - The German Human Genome-Phenome Archive
Next-generation sequencing (NGS) has revolutionized biomedical research, enabling scientist to gain more insights in the underlying genetic mechanism of various diseases. Subsequently, these scientific achievements have given rise to improved diagnostics and drug development, supporting patients to get the best therapies possible. Thereby, large-scale collection and sharing archived data with the scientific community are key factors to ensure the most possible impact in medical research.
The German Human Genome-Phenome Archive (GHGA) is funded by the German Research Foundation (DFG) and aims to provide a national infrastructure for the secure storage, analysis, and sharing of human omics data, thereby assuring that legal guidelines in Germany are met. Therefore, GHGA will operate data hubs at six NGS competence centers across Germany and will be internationally embedded in European infrastructures, becoming a national node of the European Genome Archive (EGA).
Together with the DRESDEN-concept Genome Center (DcGC), the Center for Information Services and High Performance Computing (ZIH) at the TU Dresden will form one of the six data hubs within the national GHGA-network. Thereby, the ZIH will provide the HPC, Cloud and storage capacity that are necessary to employ the GHGA infrastructure and to adequately archive generated human data records. Furthermore, it will develop, and operate a dedicated ETL pipeline for the fast transfer of data and metadata from the genome center to the final storage site. In addition, it will support DcGC scientists in running their NGS pipelines with high-performance computing to ensure the security and performance of their workflow execution.
Project webpage
Partner
ZIH contact
Project runtime
10/2020-09/2025
Funding
Das GHGA-Konsortium und seine Partner werden von der Deutschen Forschungsgemeinschaft (DFG) im Rahmen der Nationalen Forschungsdateninfrastruktur (NFDI) gefördert.