ZIH-Kolloquium
Inhaltsverzeichnis
Das ZIH-Kolloquium ist eine öffentliche Veranstaltung und findet in der Regel am 4. Donnerstag eines Monats statt. Alle wichtigen Eckdaten zu den Termine entnehmen Sie bitte der nachfolgenden Terminübersicht. Sie sind herzlich eingeladen!
14. März 2024, 15:00 MEZ, WIL-A317/ Online BBB:
Prof. Athanasius F. M. (Stan) Marée (School of Biosciences, Cardiff University, UK) - „A multi-level biophysical approach to cell motility to unravel gastrulation and somitogenesis“
The first segmented structures to appear in developing vertebrate embryos are the somites, defining the principal axis and segmentation of the animal's body plan. Somitogenesis follows a clock-like rhythm, and a range of molecular "gears" of this "clock" have been identified with expressions oscillating at that same frequency. In my talk I will argue that to unravel the mechanisms underlying this intricate morphogenetic process it is key to link our understanding of the gene regulatory processes and cell-cell signalling to the biophysics of deformation, adhesion, motility and directed migration of the cells involved. After convincing ourselves that the Cellular Potts Model is indeed a powerful framework to correctly capture such biophysical processes, I will focus on chick somitogenesis and, using the Cellular Potts Model as an integrative unit, show that the known biomolecular network and modifications in chemotaxis and adhesion can not only explain the formation of the principle axis during gastrulation, but also the segmentation into somites as a consequence of a self-organised transition from a temporal to a spatial pattern. Through this study we identify which aspects of the mechanism are robust and which are more sensitive for the specific molecular and biophysical circumstances. We will discuss how this can be related to evolutionary conserved mechanisms, and predict at which steps of the developmental process divergent solutions between species should be expected.
Stan Marée had studied biology at Utrecht University, The Netherlands, and received his PhD in Theoretical Biology and Bioinformatics in 2000 from Utrecht University for his work on mophogenesis of Dictyostelium discoideum. After a PostDoc in Mathematical Biology at the University of British Columbia, Canada, and as a staff member in the Theoretical Biology and Bioinformatics Group at Utrecht University, he founded his research group in 2010 at the Department of Computational and Systems Biology, John Innes Centre in Norwich, UK. Since 2019, Stan Marée holds the Chair in Systems and Predictive Biology at the School of Biosciences, Cardiff University, UK. He has developed, together with Paulien Hogeweg, Leah Edelstein-Keshet and Veronica Grieneisen, some of the most insightful and comprehensive computational models of self-organised patterning, of tissue morphogenesis, of cell polarity and cell motility from social microorganisms to animals to plant tissues.
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