Publications
Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology
Advances in Experimental Medicine and Biology, Vol. 777
Corbeil, Denis (Ed.) Springer Medline
2025
Karbanová, J., K. Thamm, C.A. Fargeas, I.A. Deniz, A. Lorico and D. Corbeil. (2025) Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133? J Nanobiotechnol. 23: 61 (1-39) Medline
2024
Carbone D., M.F. Santos, D. Corbeil, G. Vistoli, B. Parrino, J. Karbanová, S. Cascioferro, C. Pecoraro, J. Bauson, W. Eliwat, F. Aalam, G. Cirrincione, A. Lorico and P. Diana. (2024) Triazole derivatives inhibit the VOR complex-mediated nuclear transport of extracellular particles: potential application in cancer and HIV-1 infection. Bioorg Chem. 150: 10075899 Medline
Chen, C.-Y., G. Pearse, V. Betaneli, T. Kapustsenka, K. Hosseini, E. Fisher-Friedrich, D. Corbeil, J. Karbanová, A. Taubenberger, B. Dahncke, M. Rauner, G. Furesi, S. Perner, F. Rost, R. Jessberger. The F-actin bundler SWAP-70 promotes tumor metastasis. Life Sci Alliance. 7: e2023023007 Medline
Pleskač P., C.A. Fargeas, R. Veselska, D. Corbeil§ and J. Skoda. (§ Corresponding author) (2024) Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease. Cell Mol Biol Lett. 29: 41 Medline
Welsh, J.A., D.C.I. Goberdhan, L. O'Driscoll et al. (Co-author of the MISEV consortium). (2024) Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles. 13: e124040 Medline
Karbanová, J., I.A. Deniz, M. Wilsch-Bräuninger, R.A.S Couto, C.A. Fargeas, M.F. Santos, A. Lorico and D. Corbeil. (2024) Extracellular lipidosomes containing lipid droplets and mitochondria are released during melanoma cell division. Cell Commun Signal. 22: 57 Medline
2023
Fargeas, C.A., J. Jászai and D. Corbeil. (2023) Commentary: Prominin-1 expression in the testis/epididymis and fertility. Reprod Med Biol. 22, e12468 Medline
Santos, M.F., G. Rappa, J. Karbanová, P. Diana, G. Cirrincione, D. Carbone, D. Manna, F. Aalam, D. Wang, C. Vanier, D. Corbeil§ and A. Lorico. (§ Corresponding author) (2023) HIV-1-induced nuclear invaginations mediated by VAP-A, ORP3, and Rab7 complex explain infection of activated T-cells. Nature Commun. 4, 4588 Medline Press Release
Arena, G.O., S. Forte, M. Abdouh, C. Vanier, D. Corbeil and Aurelio Lorico. (2023) Horizontal transfer of malignant traits and the involvement of extracellular vesicles in metastasis. Cells 12, 1566 Medline
Deniz, I.A., J. Karbanová, M. Wobus, M. Bornhäuser, P. Wimberger, J.D. Kuhlmann and D. Corbeil. (2023) Mesenchymal stromal cell-associated migrasomes – A new source of chemoattractant for cells of hematopoietic origin. Cell Commun Signal 21, 36 Medline
2022
Santos, M.F., G. Rappa, S. Fontana, J. Karbanová, F. Aalam, D. Tai, Z. Li, M. Pucci, R. Alessandro, C. Morimoto, D. Corbeil§ and A. Lorico. (§ Corresponding author) (2022) Anti-human CD9 Fab fragment antibody blocks the extracellular vesicle-mediated increase in malignancy of colon cancer cells. Cells 11, 2474 Medline
Bemmerlein, L., I.A. Deniz, J. Karbanová, A. Jacobi, S. Drukewitz, Theresa Link, A. Göbel, L. Sevenich, A.V. Taubenberger, P. Wimberger, J.D. Kuhlmann and D. Corbeil. (2022) Decoding Single Cell Morphology in Osteotropic Breast Cancer Cells for Dissecting their Migratory, Molecular and Biophysical Heterogeneity. Cancers (Basel) 14: 603 (1-33) Medline
2021
Fargeas, C.A., A. Lorico, and D. Corbeil. (2021) Commentary: "Could We Address the Interplay Between CD133, Wnt/β-Catenin, and TERT Signaling Pathways as a Potential Target for Glioblastoma Therapy?” Front Oncol. 11: 1-4 (Article 712358) Medline
Santos, M.F., R. Germana, J. Karbanová, S. Fontana, M. A. Di Bella, M. R. Pope, B. Parrino, S. M. Cascioferro, G. Vistoli, P. Diana, G. Cirrincione, G.O. Arena, G. Woo, K. Huang, T. Huynh, M. Moschetti, R. Alessandro, D. Corbeil§, A. Lorico. (§ Corresponding author) (2021) Itraconazole inhibits nuclear delivery of extracellular vesicle cargo by disrupting the entry of late endosomes into the nucleoplasmic reticulum. J Extracell Vesicles 10: e12132 (1-28) Medline
Lorico, A., M. Lorico-Rappa, J. Karbanová, D. Corbeil§ and G. Pizzorno. (§ Corresponding author) (2021) CD9, a Tetraspanin Target for Cancer Therapy? Exp Biol Med. (Maywood). 246: 1121-1138 Medline
Bobinger, T., S.S. Roeder, M.I. Spruegel, K. Froehlich, V.D. Beuscher, P. Hoelter, H. Lücking, D. Corbeil and H.B. Huttner. (2020) Variation of membrane particle-bound CD133 in cerebrospinal fluid of patients with subarachnoid and intracerebral hemorrhage. J. Neurosurg. 134: 600-607 Medline
2020
Corbeil§, D., M.F. Santos, J. Karbanová, T. Kurth, G. Rappa, and A. Lorico. (§ Corresponding author) (2020) Uptake and fate of extracellular membrane vesicles: Nucleoplasmic reticulum-associated late endosomes as a new gate to intercellular communication. Cells. 9: E1931 Medline
Jászai, J., K. Thamm, J. Karbanová, P. Janich, C.A. Fargeas, W.B. Huttner and D. Corbeil. (2020) Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3. J. Biol. Chem. 295: 6007-6022 Medline
Corbeil, D. and W.B. Huttner. (2020) Protein Tyrosine Sulfation. Encyclopedia Biol. Chem. 3rd Edition. Edited by J. Jez and N. Allewell. Elsevier, Oxford. In press DOI: 10.1016/B978-0-12-809633-8.21571-9 Medline
Münsterberg, J., D. Loreth, L. Brylka, S. Werner, J. Karbanová, M. Gandrass, S. Schneegans, K. Besler, F. Hamester, J. Ramon Robador, A.T. Bauer, S. Werner Schneider, M. Wrage, K. Lamszus, J. Matschke, Y. Vashist, G. Uzunoglu, S. Steurer, A.K. Horst, L. Olivera-Ferrer, M. Glatzel, T. Schinke, D. Corbeil, K. Pantel, C. Maire, H. Wikman. (2020) ALCAM contributes to brain metastasis formation in non-small-cell lung cancer through interaction with vascular endothelium. Neuro Oncol. 22: 955-966 Medline
Fargeas, C.A., J. Karbanová, D. Corbeil. (2020) Assessment of CD133-positive extracellular membrane vesicles in pancreatic cancer ascites and beyond. Med. Mol. Morphol. 53: 60-62 Medline
Corbeil, D. and A. Lorico. (2020) Exosomes, Microvesicles, and their Friends in Solid Tumors. In Exosomes in Health and Disease. A Research and Clinical Compendium. Edited by J.R. Smythies, L.R. Edelstein, P.J. Quesenberry and D. Noble. Elsevier Company. Chapter 3: 39-80 Medline
2019
Singer, D., K. Thamm, H. Zhuang, J. Karbanová, Y. Gao, J.V. Walker, H. Jin, X. Wu, C.R. Coveney, P. Marangoni, D. Lu, P.R. Clare Grayson, T. Gulsen, K.J. Liu, S. Ardu, A. Wann, S. Luo, A.C. Zambon, A.M. Jetten, C. Tredwin, O.D. Klein, M. Attanasio, P. Carmeliet, W.B. Huttner, D. Corbeil§ and B. Hu.(§ Corresponding author).(2019) Prominin-1 governs stem cell activation by orchestrating ciliary dynamics.EMBO J. 38: pii; e99845 Medline
(This article has been selected by the GE Reports, as the 5 Coolest Things On Earth This Week, see here).
Thamm, K., D. Šimaitė, J. Karbanová, V. Bermúdez, D. Reichert, A. Morgenstern, M. Bornhäuser, W.B. Huttner, M. Wilsch-Bräuninger and D. Corbeil.(2019) Prominin-1 (CD133) modulates the architecture and dynamics of microvilli. Traffic. 20: 39-60 Medline
Corbeil D., C.A. Fargeas and J. Jászai. (2019) Deciphering the roles of prominins in the visual system. J. Biol. Chem. 294: 17166 Medline
Karbanová, J., D. Corbeil§ and C.A. Fargeas. (§ Corresponding author). (2019) Prominin-1/CD133, saliva and salivary glands – Integrating existing data to new clinical approaches. Exp. Cell Res. 383: 111566 Medline
Walker J.V., H. Zhuang, D. Singer, C. Illsley, W.L. Kok, K.K. Sivaraj, Y. Gao, C. Bolton, Y. Liu, M. Zhao, P.R.C. Grayson, S. Wang, J. Karbanová, T. Lee, S. Ardu, Q. Lai, J. Liu, M. Kassem, S. Chen, K. Yang, Y. Bai, C. Tredwin, A.C. Zambon, D. Corbeil, R. Adams, B. M. Abdallah, B. Hu. (2019) Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation. Nature Commun. 10: 3596 (1-18) Medline
Santos M.F., G. Rappa, J. Karbanová, C. Vanier, C. Morimoto, D. Corbeil§ and A. Lorico. (§ Corresponding author). (2019) Anti-human CD9 antibody Fab fragment impairs the internalization of extracellular vesicles and the nuclear transfer of their cargo proteins. J. Cell Mol. Med. 23: 4408-4421 Medline
2018
Santos, M.F., G. Rappa, J. Karbanová, T. Kurth, D. Corbeil§ and A. Lorico (§ Corresponding author). (2018) VAMP-associated protein-A and oxysterol-binding protein–related protein 3 promote the entry of late endosomes into the nucleoplasmic reticulum. J. Biol. Chem. 293: 13834-13848 Medline
Karbanová, J., A. Lorico, M. Bornhäuser, D. Corbeil§ and C.A. Fargeas. (§ Corresponding author). (2018) Prominin-1/CD133: Lipid Raft Association, Detergent Resistance and Immunodetection. Stem Cells Transl Med. 7: 155-160 Medline
Maehara R., K. Fujikura, K. Takeuchi, M. Akita, S. Abe-Suzuki, J. Karbanová, D. Corbeil, T. Itoh, Y. Kakeji and Y. Zen. (2018) SOX2-silenced squamous cell carcinoma: A highly malignant form of esophageal cancer with SOX2 promoter hypermethylation. Mod. Pathol. 31: 83-92 Medline
2017
Bachor, T.P., J. Karbanová, E. Büttner, V. Bermúdez, M. Marquioni Ramella, P. Carmeliet, D. Corbeil§and A.M. Suburo§. (§ Corresponding authors).Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type-2 diabetes. Neurobiol. Dis.108: 13-28 Medline
Lorico, A., G. Rappa, D. Corbeil, T.T. Le. Observation-driven inquiry: Raman spectroscopic imaging illuminates cancer lipid metabolism. Stem Cell Investig. 4.42 Medline
Bobinger, T., L. May, H. Lücking, S.P. Kloska, P. Burkardt, P. Spitzer, J.M. Maler, D. Corbeil and H.B. Huttner. (2017) CD133-positive membrane particles in cerebrospinal fluid of patients with inflammatory and degenerative neurological diseases. Front. Cell. Neurosci.11: 1-9 Medline
Rappa, G., M.F. Santos, T.M. Green, J. Karbanová, J. Hassler, Y. Bai, S.H. Barsky, D. Corbeil§ and Aurelio Lorico. (§ Corresponding author). (2017)Nuclear transport of cancer extracellular vesicle-derived biomaterials through nuclear envelope invagination-associated late endosomes. Oncotarget8: 14443-14461. Medline
Sakai, Y., S.-M. Hong, S. An,J.Y. Kim, D. Corbeil, J.Karbanová, K. Otani, K. Fujikura, K.B. Song, S.C. Kim,M. Akita, Y. Nanno, H. Toyama, T. Fukumoto, Y. Ku, T. Hirose, T. Itoh and Y. Zen. CD133 expression in well-differentiated pancreatic neuroendocrine tumors: A potential predictor of progressive clinical courses. Hum Pathol61: 148-157> Medline
2016
Thamm, K., S. Graupner, C. Werner, W.B. Huttner and D. Corbeil. (2016) Monoclonal Antibodies 13A4 and AC133 Do Not Recognize the Canine Ortholog of Mouse and Human Stem Cell Antigen Prominin-1 (CD133). PLoS One 11: e0164079 Medline
Fargeas, C.A., and D. Corbeil. (2016) Comments on the “Prognostic Impact and Clinicopathological Correlation of CD133 and ALDH1 Expression in Invasive Breast Cancer” and the “Commentary by Antonio Ieni and Giovanni Tuccari” J Breast Cancer 9: 336-338 Medline
Santos-Ferreira, T., M. Völkner, O. Borsch, J. Haas, P. Cimalla, P. Vasudevan, P. Carmeliet, D. Corbeil, S. Michalakis, E. Koch, M.O. Karl and M. Ader. (2016) Author Response: Possibility of cytoplasmic transportation between donor-host cell following photoreceptor transplantation.Invest. Ophthalmol. Vis. Sci. 57: 5336-5337 Medline
Reichert, D., J. Scheinpflug, J. Karbanová, D. Freund, M. Bornhäuser, D. Corbeil. Tunnelling nanotubes mediate the transfer of stem cell marker CD133 between hematopoietic progenitor cells. Exp Hematol. 44:1092-1112 Medline Front Cover
Niehage, C., J. Karbanová, C. Steenblock, D. Corbeil* and B. Hoflack*. (*Equal contribution) (2016) Cell surface proteome of dental pulp stem cells identified by label-free mass spectrometry. PloS One11: e0159824 Medline
Santos-Ferreira, T., M. Völkner, O. Borsch, J. Haas, P. Cimalla, P. Vasudevan, P. Carmeliet, D. Corbeil, S. Michalakis, E. Koch, M.O. Karland M. Ader. Stem cell-derived photoreceptor transplants differentially integrate into mouse models of cone-rod dystrophy. Invest. Ophthalmol. Vis. Sci. 57: 3509-3520 Medline
2015
Reichert, D., J. Friedrichs, S. Ritter, T. Käubler, C. Werner, M. Bornhäuser and D. Corbeil. Phenotypic, morphological and adhesive differences of human hematopoietic progenitor cells cultured on murine versus human mesenchymal stromal Cells. Sci Rep. 5: 15680 Medline
Gouveia de Andrade, A.V., G. Bertolino, J. Riewaldt, K. Bieback, J. Karbanová, M. Odendahl, M. Bornhäuser, M. Schmitz, D. Corbeil, and T. Tonn.Extracellular vesicles secreted by bone marrow- and adipose tissue-derived mesenchymal stromal cells fail to suppress lymphocyte proliferation. Stem Cells Dev. 24: 1374-1376 Medline
Fargeas, C.A., E. Büttner, and D. Corbeil. Commentary: "Prom1 function in development, intestinal inflammation, and intestinal tumorigenesis" Front Oncol. 5: 1-4 Medline
Jászai, J., D. Corbeil§and C.A. Fargeas.(§ corresponding author) Comprehensive overview of CD133 biology in neural tissues across species. In Neural surface antigens – from basic biology towards biomedical applications. Edited by J. Pruszak. Elsevier Company. Chapter 10: 113-129
Rappa, G., T.M. Green, J. Karbanová, D. Corbeil and A. Lorico. Tetraspanin CD9 Determines Invasiveness and Tumorigenicity of Human Breast Cancer Cells. Oncotarget 6: 7970-7991 Medline
Rappa, G., C.A. Fargeas, T.T. Le, D. Corbeiland A. Lorico.An Intriguing Relationship between Lipid Droplets, Cholesterol-Binding Protein CD133 and Wnt/b-catenin Signaling Pathway in Carcinogenesis. Stem Cells 33: 1366-1370 Medline
2014
Karbanová, J., J. Laco, A-M. Marzseco, P. Janich, M. Voborníková, J. Mokrý, C.A. Fargeas, W.B. Huttner and D. Corbeil. Human prominin-1 (CD133) is detected in both neoplastic and non-neoplastic salivary gland diseases and released into saliva in a ubiquitinated form. PLoS One 9: e98927 Medline
Corbeil, D., C.A. Fargeas and J. Jászai. CD133 might be a pan marker of epithelial cells with dedifferentiation capacity. Proc. Natl. Acad. Sci. USA 111: E1451-1452 Medline>
2013
Jászai, J., S. Graupner, E.M. Tanaka, R.H.W. Funk, W.B. Huttner, M. Brand and D. Corbeil. Spatial distribution of prominin-1 (CD133)–positive cells within germinative zones of the vertebrate brains. PLoS One, 8: e63457 Medline
Arndt K., T. Grinenko, N. Mende, D. Reichert, M. Portz, T. Ripich, P. Carmeliet, D. Corbeil and C. Waskow. CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 110: 5582-5587 Medline
Walker, T.L., A. Wierick, A.M. Sykes, B. Waldau, D. Corbeil, P. Carmeliet and G. Kempermann. Prominin-1 allows prospective isolation of neural stem cells from the adult murine hippocampus. J Neurosci. 33: 3010-3024 Medline
Corbeil, D., J. Karbanová, C.A. Fargeas and J. Jászai. Prominin-1 (CD133): Molecular and cellular features across species. In Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology. Edited by D. Corbeil. Springer Company. Adv Exp Med Biol. 777: 3-24 Medline
Gurudev, N., M. Florek, D. Corbeil and E. Knust. Prominent role of prominin in the retina. In Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology. Edited by D. Corbeil. Springer Company. Adv Exp Med Biol. 777: 55-71 Medline
Bernstein, P., I. Sperling, D. Corbeil, U. Hempel, S. Fickert. Progenitor cells from cartilage: no osteoarthritis-grade-specific differences in stem cell marker expression. Biotechnol. Prog. 29: 206-12 Medline
Rappa, G., J. Mercapide, F. Anzanello, T.T. Le, M.G. Johlfs, R.R. Fiscus, M. Wilsch-Bräuninger, D. Corbeil and A. Lorico. Wnt Interaction and extracellular release of prominin-1/CD133 in human malignant melanoma cells. Exp Cell Res. 319: 810-819 Medline
Wittig, D., J. Jászai, D. Corbeil and R.H.W. Funk. Immunohistochemical localization and characterization of putative mesenchymal stem cell markers in the retinal capillary network of rodents. Cells Tiss Org. 2: 344-359 Medline
Grosse-Gehling, P., C.A. Fargeas, C. Dittfeld, Y. Garbe, M.R. Alison, D. Corbeil and L.A. Kunz-Schughart. CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges. J Pathol. 229: 355-78 Medline
2012
Eberle, D., T. Kurth, T. Santos-Ferreira, J. Wilson, D. Corbeil and M. Ader. Outer segment formation of transplanted photoreceptor precursor cells. PLoS One 7: e46305 Medline
Fonseca, A.-V., D. Reichert and D. Corbeil. Migration of stem cells – Role of the RhoA / ROCK I pathway (Method). Stem Cells and Cancer Stem Cells 6: 319-331 Medline
Huttner, H.B., D. Corbeil, C. Thirmeyer, R. Coras, M. Köhrmann, C. Mauer, J.B. Kuramatsu, S. Kloska, A. Doerfler, D. Weigel, J, Klucken, J, Winkler, E, Pauli, S. Schwab, H.M. Hamer and B.S. Kasper. Increased membrane shedding - indicated by an elevation of CD133-enriched membrane particles - into the CSF in partial epilepsy. Epilepsy Res. 99: 101-6 Medline
2011
Ettinger, A.W., M. Wilsch-Bräuninger, A.-M. Marzesco, M. Bickle, A. Lohmann, Z. Maliga, J. Karbanová, D. Corbeil, A.A. Hyman and W.B. Huttner. Proliferating versus differentiating stem and cancer cells exhibit distinct midbody release behavior. Nature Commun. 2: 503 (1-12) Medline
Fargeas, C.A., J. Karbanová, J. Jászai and D. Corbeil. CD133 and membrane microdomains ? Old facets for future hypotheses. World J Gastroenterol. 17: 4149-4152 Medline
Lathia, J.D., M. Hitomi, J. Gallagher, S.P. Gadani, J. Adkins, A. Vasanji, L. Liu, C.E. Eyler, J.M. Heddleston, Q. Wu, S. Minhas, A. Soeda, D.J. Hoeppner, R. Ravin, R.D.G. McKay, R.E. McLendon, D. Corbeil, A. Chenn, A.B. Hjelmeland, D.M. Park and J.N. Rich. Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions. Cell Death Dis. 2: e200 Medline
Eberle, D., S. Schubert, K. Postel, D. Corbeil, M. Ader. Increased integration of transplanted CD73-positive photoreceptor precursors into adult mouse retina. Invest. Ophthalmol. Vis. Sci. 52: 6462-6471 Medline
Niehage, C., C. Steenblock, T. Pursche, M. Bornhäuser, D. Corbeil and B. Hoflack. The cell surface proteome of human mesenchymal stromal cells. PloS One. 6: e20399 Medline
Bauer, N., M. Wilsch-Bräuninger, J. Karbanová, A.-V. Fonseca, D. Strauss, D. Freund, C. Thiele, W.B. Huttner, M. Bornhäuser and D. Corbeil. Hematopoietic stem cell differentiation promotes the release of prominin-1/CD133?containing membrane vesicles ? A role of the endocytic-exocytic pathway. EMBO Mol. Med. 3: 398-409 Medline
Zen, C., Y. Zen, R.R. Mitry, D. Corbeil, J. Karbanová, J. O?Grady, J. Karani, P. Kane, N. Heaton, B.C. Portmann, and A. Quaglia. Mixed phenotype hepatocellular carcinoma after trans-arterial chemoembolization (TACE) and liver transplantation. Liver Transplant. 17: 943-954 Medline
Jászai, J., C.A. Fargeas, S. Graupner, E.M. Tanaka, M. Brand, W.B. Huttner and D. Corbeil. Distinct and conserved prominin-1/CD133-positive retinal cell populations identified across species. PloS One. 6: e17590 Medline
Fonseca, A.-V. and D. Corbeil. The hematopoietic stem cell polarization and migration: A dynamic link between RhoA signaling pathway, microtubule network and ganglioside-based membrane microdomains. Commun Integr Biol. 4: 201-204 Front Cover Medline
Fickert, S., U. Schröter-Bobsin, A.F. Groß, U. Hempel, C. Wojciechowski, C. Rentsch, D. Corbeil and K.P. Günther. Human mesenchymal stem cell proliferation and osteogenic differentiation during long-term ex vivo cultivation is not age dependent. J. Bone Miner. Metab. 29: 224-235 Medline
Karbanová, J., T. Soukup, J. Suchánek, R. Pytlík, D. Corbeil and J. Mokrý. Characterization of dental pulp stem cells from impacted third molars cultured in low-serum containing medium. Cells Tissues Organs. 193: 344-365 Medline
Missol-Kolka, E., J. Karbanová, P. Janich, M. Haase, C.A. Fargeas, W.B. Huttner and D. Corbeil. Prominin-1 (CD133) is not restricted to stem cells located in the basal compartment of murine and human prostate. The Prostate. 71: 254-263 Medline
2010
Fonseca, A.-V., D. Freund, M. Bornhäuser and D. Corbeil. Polarization and migration of hematopoietic stem and progenitor cells rely on RhoA/ROCK I pathway and an active reorganization of the microtubule network. J. Biol. Chem. 285: 31661-31671 Medline
Fietz, S.A., I. Kelava, J. Vogt, Wilsch-Bräuninger D. Stezel, J.L. Fish, D. Corbeil, Riehn, W. Distler, R. Nitsch and W.B. Huttner. Outer subventricular zone progenitors of human and ferret cerebral cortex retain epithelial properties and expand via integrin signaling.
Nature Neurosci.13: 690-699 Medline
Jászai, J., L.M. Farkas, C.A. Fargeas, P. Janich, M. Haase, W.B. Huttner and D. Corbeil. Prominin-2 is a novel marker of distal tubules and collecting ducts of the human and murine kidney. Histochem. Cell Biol. 133: 527-539 Medline
Jing, D., A.-V. Fonseca, N. Alakel, F.A. Fierro, K. Muller, M. Bornhäuser, G. Ehninger, D. Corbeil and R. Ordemann. Hematopoietic stem cells in coculture with mesenchymal stromal cells - modelling the niche compartments in-vitro. Haematologica. 95: 542-550 Medline
Hundsdoerfer, A.K., M. Sanetra, D. Corbeil and H. Stuckas. Eleven Hawkmoth Microsatellite Loci of Canary Island Hyles tithymali (Lepidoptera). Conservation Genet. Resour. 2: 241-244 Medline
Corbeil, D., A,-M. Marzesco, M. Wilsch-Bräuninger and W.B. Huttner. The intriguing links between prominin-1 (CD133), cholesterol-based membrane microdomains, remodeling of apical plasma membrane protrusions, extracellular membrane particles, and (neuro)epithelial cell differentiation. FEBS Lett. 584: 1659-1664 Medline
Freund, D., A.-V. Fonseca, P. Janich, M. Bornhäuser and D. Corbeil. Differential expression of biofunctional GM1 and GM3 gangliosides within the plastic-adherent multipotent mesenchymal stromal cell population. Cytotherapy. 12:131-142 Medline
Corbeil, D., A.-M. Marzesco, C.A. Fargeas, and W.B. Huttner. Prominin-1, a distinct cholesterol?binding membrane protein, and the organisation of the apical plasma membrane of epithelial cells. Subcell. Biochem. 51:399-423 Medline
2009
Gedye, C., J. Quirk, J. Browning, S. Svobodova, T. John, P Sluka, P.R. Dunbar, D. Corbeil, J., Cebon and I.D. Davis. Cancer/testis antigens can be immunological targets in clonogenic CD133+ melanoma cells. Cancer Immunol. Immunother. 58:1635-1646 Medline
Marzesco, A.-M., M. Wilsch-Bräuninger, V. Dubreuil, P. Janich, K. Langenfeld, C. Thiele, W.B. Huttner and D. Corbeil. Release of extracellular membrane vesicles from microvilli of epithelial cells is enhanced by depleting membrane cholesterol. FEBS Lett. 583:897-902 Medline
Zacchigna, S., H. Oh, M. Wilsch-Bräuninger, E. Missol-Kolka, M. J. Jászai, S. Jansen, N. Tanimoto, F. Tonagel, M. Seeliger, W.B. Huttner, D. Corbeil, M. Dewerchin, S. Vinckier, L. Moons and P. Carmeliet. Loss of cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration. J. Neurosci. 29: 2297-2308 Medline
Bernstein, P., M. Dong, D. Corbeil, M. Gelinsky, K.-P. Günther and S. Fickert. Pellet culture elicits superior chondrogenic redifferentiation than alginate-based systems. Biotechnol. Prog. 25:1146-1152
Corbeil, D., A. Joester, C.A. Fargeas, J. Jászai, J. Garwood, H.B. Werner and W.B. Huttner. (§ corresponding author). Expression of distinct splice variants of the stem cell marker Prominin-1 (CD133) in glial cells. Glia. 57:860-874 Medline
Bernstein, P., M. Dong, S. Graupner, D. Corbeil, M. Gelinsky, K.-P. Günther and S. Fickert. Sox9 expression of alginate-encapsulated chondrocytes is stimulated by low cell density. J. Biomed. Mat. Res. Part A. 91:910-918 Medline
Siebzehnrübl, F.A., I. Jesker, D. Müller, R. Buslei, R. Coras, E. Hahnen, H.B. Huttner, D. Corbeil, J. Kaesbauer, T. Appl, S. von Hörsten and I. Blümcke. Spontaneous in vitro transformation of adult neural precursors into stem-like cancer cells. Brain Pathol. 19:399-408 Medline
2008
Karbanová, J., E. Missol-Kolka, A.-V. Fonseca, C. Lorra, P. Janich, H. Hollerová, J. Jászai, J. Ehrmann, Z. Kolá?, C. Liebers, S. Arl, D. ?ubrtová, D. Freund, J. Mokrý, W.B. Huttner and D. Corbeil. The stem cell marker CD133 (Prominin-1) is expressed in various human glandular epithelia. J Histochem Cytochem. 56:977-993 Medline Suppl. Mat.
Yang, Z., Y. Chen, C.Lillo, J. Chien, M. Michaelides, M. Klein K.A. Howes, Y. Li, Y. Kaminoh, H. Chen, C. Zhao, Y. Chen, Y.T. Al-Sheikh, G. Karan, D. Corbeil, P. Escher, S. Kamaya, C. Li, S. Johnson, J.M. Frederick, Y. Zhao, C. Wang, D.J. Cameron, W.B. Huttner, D.F. Schorderet, F.L. Munier, A.T. Moore, D.G. Birch, W. Baehr, D. M. Hunt, D.S. Williams and K. Zhang. Mutant prominin-1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J Clin Invest. 118:2908-2916 Medline
Jászai, J., C.A. Fargeas, M. Haase, L.M. Farkas, W.B. Huttner and D. Corbeil. Robust expression of Prominin-2 all along the adult male reproductive system and urinary bladder. Histochem Cell Biol. 130:749-759 Medline
Fonseca, A.-V., N. Bauer and D. Corbeil. The stem cell marker CD133 meets the endosomal compartment ? New insights into the cell division of hematopoietic stem cells. Blood Cells Mol Dis. 41: 194-195 Medline Suppl. Mat.
Huttner, H.B., P. Janich, M. Köhrmann, J. Jászai, F. Siebzehnrubl, I. Blümcke, M. Suttorp, M. Gahr, D. Kuhnt, C. Nimsky, D. Krex, G. Schackert, K. Löwenbrück, H. Reichmann, E. Jüttler, W. Hacke, P. D. Schellinger, S. Schwab, M. Wilsch-Bräuninger, A.-M. Marzesco, and D. Corbeil. The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying CNS disease. Stem Cells. 26: 698-705 Medline
Bauer, N., A.-V. Fonseca, M. Florek, D. Freund, J. Jászai, M. Bornhäuser, C.A. Fargeas and D. Corbeil. New insights into the cell biology of hematopoietic progenitors by studying prominin-1 (CD133). Cells Tiss Org. 188: 127-138 Medline Front Cover
Lardon, J., D. Corbeil, W.B. Huttner, Z. Ling and L. Bouwens. Stem cell marker prominin 1/AC133 is expressed in duct cells of the adult human pancreas. Pancreas. 36: e1-e6 Medline
2007
Jászai, J., C.A. Fargeas, M. Florek, W.B. Huttner and D. Corbeil. Focus on Molecules: Prominin-1 (CD133). Exp. Eye Res. 85: 585-586 Medline
Jászai, J., P. Janich, L.M. Farkas, C.A. Fargeas, W.B. Huttner and D. Corbeil. Differential expression of Prominin-1 (CD133) and Prominin-2 in major cephalic exocrine glands of adult mice. Histochem Cell Biol. 128: 409-419 Medline
Janich, P. and D. Corbeil. GM1 and GM3 gangliosides highlight distinct lipid microdomains within the apical domain of epithelial cells. FEBS Lett. 581: 1783-1787 Medline
Fargeas, C.A., W.B. Huttner and D. Corbeil. Nomenclature of prominin-1 (CD133) splice variants â?? An update. Tissue Antigens. 69: 602-606 Medline
Rammelt, S., D. Corbeil, S. Manthey, H, Zwipp and U. Hanisch. Immunohistochemical in-situ characterization of orthopaedic implants on PMMA embedded cutting and grinding sections. J. Biomed. Mat. Res. Part A. 83: 313-322 Medline
Dubreuil, D., A.-M. Marzesco, D. Corbeil, W.B. Huttner and M. Wilsch-Bräuninger. Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1. J. Cell Biol. 176: 483-495 Medline
Sicard, F., M. Ehrart-Bornstein, D. Corbeil, S. Sperber, A.W. Krug, C.G. Ziegler, V. Rettori, S.M. McCann and S.R. Bornstein. Growth factors, DHEA and DHEAS regulate chromaffin cell proliferation in an age-dependent manner. Proc. Natl. Acad. Sci. USA. 104: 2007-2012 Medline
Florek, M., N. Bauer, P. Janich, M. Wilsch-Braeuninger, C.A. Fargeas, A.-M. Marzesco, C. Thiele, G. Ehninger, W.B. Huttner and D. Corbeil. Prominin-2 is a cholesterol-binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into the urine. Cell Tissue Res. 328: 31-47 MedlineFront Cover
2006
Freund, D., N. Bauer S. Boxberger, B. Jørgensen, S. Feldmann, G. Ehninger, C. Werner, M. Bornhäuser, J. Oswald and D. Corbeil. Polarization of human hematopoietic progenitors during contact with multipotent mesenchymal stromal cells ? effects on proliferation and clonogenicity. Stem Cells Dev. 15: 815-829 Medline Front Cover
Freund, D., J. Oswald, S. Feldmann, G. Ehninger, D. Corbeil and M. Bornhäuser. Comparative analysis of proliferative potential and clonogenicity of MACS-immunomagnetic isolated CD34+ and CD133+ blood stem cells derived from a single donor. Cell Prolif. 39: 325-332 Medline
Fargeas, C.A., A.-V. Fonseca, W.B. Huttner and D. Corbeil. Prominin-1 (CD133) ? from progenitor cells to human diseases. Future Lipidology. 2: 213-225 Medline
2005
Marzesco, A-M., P. Janich, M. Wilsch-Bräuninger, V. Dubreuil, K. Langenfeld, D. Corbeil and W.B. Huttner. Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells. J. Cell Sci.118: 2849-2858 Medline
Lee, A., J.D. Kessler, T.-A. Read, C. Kaiser, D. Corbeil, W.B. Huttner, J.E. Johnson, R.J. Wechsler-Reya. Isolation of neural stem cells from postnatal cerebellum. Nat. Neurosci. 8: 715-719 Medline
Kania, G., D. Corbeil, J. Fuchs, K.V. Tarasov, P. Blyszczuk, W.B. Huttner, K.R. Boheler and A.M. Wobus. The somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors. Stem Cells. 23: 791-804 Medline
Corbeil, D., C. Thiele and W. B. Huttner. Tyrosine sulfation (Unit 14.7). Current Protocols in Protein Science. Edited by J. Colligan, B.M. Dunn. D.W. Speicher and P.T. Wingfield. Wiley & Sons Press. Suppl. 39:14.7.1-14.7.14
Florek, M., M. Haase, A.-M. Marzesco, D. Freund, G. Ehninger, W. B. Huttner and D. Corbeil. Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer. Cell Tissue Res. 319: 15-26 Medline
Bornhäuser, M., L. Eger, U. Oelschlaegel, S. Auffermann-Gretzinger, A. Kiani, J. Schetelig, T. Illmer, M. Schaich, D. Corbeil, C. Thiede and G. Ehninger. Rapid reconstitution of dendritic cells after allogeneic transplatation of CD133+ selected hematopoietic stem cells. Leukemia. 19: 161-165
2004
Fargeas, C.A., A. Joester, E. Missol-Kolka, A. Hellwig, W.B. Huttner and D. Corbeil. Identification of novel Prominin-1/CD133 splice variants with alternative C-termini and their expression in epididymis and testis. J. Cell Sci. 117: 4301-4311 Medline
Corbeil, D., and W.B. Huttner. Tyrosine Sulfation. Encyclopedia Biol. Chem. Edited by W. Lennarz and M.D. Lane. Elsevier, Oxford. 4: 294-297
Giebel, G., D. Corbeil, J. Beckmann, J. Höhn, D. Freund, K. Giesen, G. Kögler and P. Wernet. Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells. Blood. 104: 2332-2338 Medline
Kosodo, Y., K. Röper, W. Haubensak, A.-M. Marzesco, D. Corbeil and W.B. Huttner. Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells. EMBO J. 23: 2314-2324 Medline
2003
Fargeas, C.A., D. Corbeil and W.B. Huttner. AC133 antigen, CD133, prominin-1, prominin-2, Etc.: Prominin family gene products in need of a rational nomenclature. Stem Cells. 21: 506-508 Medline
Fargeas, C.A., M. Florek, W.B. Huttner and D. Corbeil. Characterization of Prominin-2, a new member of the prominin family of pentaspan membrane glycoproteins. J. Biol. Chem. 278: 8586-8596 Medline
2002
Rustom, A., M. Bajohrs, C. Kaether, P. Keller, D. Toomre, D. Corbeil and H.-H. Gerdes. Selective delivery of secretory cargo in Golgi-derived carriers of nonepithelial cells. Traffic. 3: 279-288
2001
Corbeil, D., C. A. Fargeas and W.B. Huttner. Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein. Biochem. Biophys. Res. Commun. 285: 939-944 Medline
Corbeil, D., K. Röper, C.A. Fargeas, A. Joester and W.B. Huttner. Prominin: A story of cholesterol, plasma membrane protrusions and human pathology. Traffic. 2: 82-91 Medline
2000
Röper*, K., D. Corbeil* and W.B. Huttner. (*joint first authors). Retention of prominin in microvilli reveals distinct cholesterol-based lipid microdomain within the apical membrane of epithelial cells. Nature Cell Biol. 2: 582-592 Medline
Corbeil, D., K. Röper, A. Hellwig, M. Tavian, S. Miraglia, S.M. Watt, P.J. Simmons, B. Peault, D.W. Buck and W.B. Huttner. The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted in membrane protrusions. J. Biol. Chem. 275: 5512-5520 Medline
Röper*, K., D. Corbeil* and W.B. Huttner. (*joint first authors). Distinct lipid microdomains within the apical plasma membrane of polarized epithelial cells. A potential role of the lipid bilayer in the retention of prominin in microvilli. In Protein, Lipid and Membrane Traffic: Pathway and Targeting. Edited by Jos A.F. Op den Kamp. IOS Press. NATO Science Series. Vol. 322: 73-84
Maw, M.A., D. Corbeil, J. Koch, A. Hellwig, J.C. Wilson-Wheeler, R.J. Bridges, G. Kumaramanickavel, S. John, D. Nacarrow, K. Röper, A. Weigmann, W.B. Huttner and M.J. Denton. A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration. Hum. Mol. Genet. 9: 27-34 Medline
1999
Corbeil, D., K. Röper, M.J. Hannah, A. Hellwig and W.B. Huttner. Selective localization of the polytopic membrane protein prominin in microvilli of epithelial cells- A combination of apical sorting and retention in plasma membrane protrusions. J. Cell Sci. 112: 1023-1033 Medline
1998
Beißwanger, R., D. Corbeil, C. Vannier, C. Thiele, U. Dohrmann, R. Kellner, K. Ashman, C. Niehrs and W.B. Huttner. Existence of distinct tyrosylprotein sulfotransferase genes: Molecular characterization of tyrosylprotein sulfotransferase-2. Proc. Natl. Acad. Sci. USA. 95: 11134-11139
Corbeil, D., K. Röper, A. Weigmann and W.B. Huttner. AC133 hematopoietic stem cell antigen: human homologue of mouse kidney prominin, or distinct member of a novel protein family? Blood. 91: 2625-2626 Medline
1997
Weigmann* A., D. Corbeil*, A. Hellwig and W.B. Huttner. (*joint first authors). Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of nonepithelial cells. Proc. Natl. Acad. Sci. USA. 94: 12425-12430 Medline
1995
Huttner, W.B., M. Ohashi, R.H. Kehlenbach, F.A. Barr, R. Bauerfeind, O. Bräunling, D. Corbeil, M. Hannah, H.A. Pasolli, A. Schmidt, A.A. Schmidt, C. Thiele, Y. Wang, A. Krömer and H.-H. Gerdes. Biogenesis of neurosecretory vesicles. Cold Spring Harb. Symp. Quant. Biol. 60: 315-327
Milhiet, P.-E., S. Chevallier, D. Corbeil, N.G. Seidah, P. Crine and G. Boileau. Proteolytic processing of the alpha subunit of rat endopeptidase-24.18 by furin. Biochem. J. 309: 683-688
1994
Milhiet, P.-E., D. Corbeil, V. Simon, A.J. Kenny, P. Crine and G. Boileau. Expression of rat endopeptidase-24.18 in COS-1 cells: membrane topology and activity. Biochem. J. 300: 37-43
1993
Corbeil, D., P.-E. Milhiet, V. Simon, J. Ingram, A.J. Kenny, G. Boileau and P. Crine. Rat endopeptidase-24.18 alpha subunit is secreted into the culture medium as a zymogen when expressed by COS-1 cells. FEBS Lett. 335: 361-366
Crine, P., F. Jalal, C. Lanctôt, D. Corbeil, G. Waksman, G. Lemay, K. Withers and G. Boileau. Targeting of neutral endopeptidase-24.11 in polarized cells. Biochem. Soc. Trans. 21: 668-672
1992
Jalal, F., C. Jumarie, W. Bawab, D. Corbeil, C. Malo, A. Berteloot and P. Crine. Polarized distribution of neutral endopeptidase 24.11 at the cell surface of cultured human intestinal epithelial Caco-2 cells. Biochem. J. 288: 945-951
Corbeil, D., F. Gaudoux, S. Wainwright, J. Ingram, A. J. Kenny, G. Boileau and P. Crine. Molecular cloning of the alpha-subunit of rat endopeptidase-24.18 (endopeptidase-2) and co-localization with endopeptidase-24.11 in rat kidney by in situ hybridization. FEBS Lett. 309: 203-208
Corbeil, D., G. Boileau, G. Lemay and P. Crine. Expression and polarized apical secretion in Madin-Darby canine kidney cells of a recombinant soluble form of neutral endopeptidase lacking the cytosolic and transmembrane domains. J. Biol. Chem. 267: 2798-2801