The aim of the call is to facilitate multinational, collaborative research projects that will address critical translational and clinical questions to improve our knowledge concerning the role of bidirectional central nervous system-body interactions on the genesis and progression of neurological and psychiatric diseases. A better understanding of these interactions has the potential to uncover solutions to prevent and treat those disorders.

The central nervous system and other body compartments are highly interconnected. The central nervous system affects physiological functions through signals transmitted from the brain to the body and vice versa. Signals from peripheral organs to the brain could be derived from the immune system, metabolic processes, gut-brain axis and microbiome, among others. Dysregulation of the brain-body communication may cause severe brain disorders. The roles of the signals and their pathways for regulating brain functions are poorly understood. Consequently, the associated pathophysiological mechanisms leading to central nervous system disorders and their related co-morbidities are largely unknown.

The NEURON funding organizations particularly strive to fund multidisciplinary and translational research proposals that combine basic, clinical and/or technological approaches. The consortia should submit novel, ambitious ideas that can only be achieved by the complementary collaboration between partners.

Research proposals should cover at least one of the following areas:

a) Fundamental research on the role of the bidirectional brain-body interaction on the pathogenesis and/or aetiology of neurological and psychiatric diseases. This may include the development of innovative or shared resources and technologies considered of relevance in the context of this call.

b) Pre-clinical and clinical research to develop new strategies for prevention, diagnosis, therapy, and rehabilitation procedures for diseases in which alterations in brain-body communication constitutes a relevant process of the pathology.

The following research areas are excluded from this call:

• Neurodegenerative disorders that are addressed by the EU Joint Programme –Neurodegenerative Disease Research (JPND).
• Proposals focusing on neuro-oncology.
• Proposals dealing primarily with periphery organ functions (e.g. lung, sensory organs, liver,
• cardiovascular, etc.) without specifically focusing on the brain-body interaction aspect.
• Proposals focusing solely on technological developments in disregard of neurobiological mechanisms.

Timeline and eligibility criteria:

• 08.03.2024 – pre-proposal submission
• 28.06.2024 – full-proposal submission
• Funding for transnational joint projects with min 3 partner from 3 participating funding organisations
• maximum of 5 partners
• max. 360.000 EUR German funding per consortium
• Involvement of early career researchers as consortium partners is highly encouraged

Participating countries:

Belgium, Croatia, France, Germany, Hungary*, Israel, Italy, Latvia, Lithuania, Norway, Poland, Romania, Slovakia, Spain, Switzerland, Taiwan, Turkey

*Decision pending

Further information:

https://www.neuron-eranet.eu/joint-calls/bio-medical/2024-brain-body/

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Mr Dr. Stefan Schuldt

ERA-Nets, BMBF Complementary measures

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