Publikationen
2021
Subramanian P, Gargani S, Palladini A, Chatzimike M, Grzybek M, Peitzsch M, Papanastasiou AD, Pyrina I, Ntafis V, Gercken B, Lesche M, Petzold A, Sinha A, Nati M, Thangapandi VR, Kourtzelis I, Andreadou M, Witt A, Dahl A, Burkhardt R, Haase R, Domingues AMJ, Henry I, Zamboni N, Mirtschink P, Chung KJ, Hampe J, Coskun Ü, Kontoyiannis DL, Chavakis T. The RNA binding protein human antigen R is a gatekeeper of liver homeostasis. Hepatology. 2021 Sep 14. doi: 10.1002/hep.32153.
Vvedenskaya O, Rose TD, Knittelfelder O, Palladini A, Wodke JAH, Schuhmann K, Ackerman JM, Wang Y, Has C, Brosch M, Thangapandi VR, Buch S, Züllig T, Hartler J, Köfeler HC, Röcken C, Coskun Ü, Klipp E, von Schoenfels W, Gross J, Schafmayer C, Hampe J, Pauling JK, Shevchenko A. Nonalcoholic fatty liver disease stratification by liver lipidomics. J Lipid Res. 2021 Aug 10;62:100104. doi: 10.1016/j.jlr.2021.100104.
Sormendi S, Deygas M, Sinha A, Bernard M, Krüger A, Kourtzelis I, Le Lay G, Sáez PJ, Gerlach M, Franke K, Meneses A, Kräter M, Palladini A, Guck J, Coskun Ü, Chavakis T, Vargas P, Wielockx B. HIF2α is a direct regulator of neutrophil motility. Blood. 2021 Jun 17;137(24):3416-3427. doi: 10.1182/blood.2020007505.
Ansarullah, Jain C, Far FF, Homberg S, Wißmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenländer L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Müller TD, Meier M, Tschöp MH, Coskun Ü, Lickert H. Author Correction: Inceptor counteracts insulin signalling in β-cells to control glycaemia. Nature. 2021 Apr;592(7852):E1. doi: 10.1038/s41586-021-03347-z.
Ansarullah, Jain C, Far FF, Homberg S, Wißmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenländer L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Müller TD, Meier M, Tschöp MH, Coskun Ü, Lickert H. Inceptor counteracts insulin signalling in β-cells to control glycaemia. Nature. 2021 Feb;590(7845):326-331. doi: 10.1038/s41586-021-03225-8.
2020
Schuhmacher M, Grasskamp AT, Barahtjan P, Wagner N, Lombardot B, Schuhmacher JS, Sala P, Lohmann A, Henry I, Shevchenko A, Coskun Ü, Walter AM, Nadler A. Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7729-7738. doi: 10.1073/pnas.1912684117.
2019
Gutmann,T., Schäfer, I.B., Poojari, C., Brankatschk, B., Vattulainen, I., Strauss, M., Coskun, Ü. (2019) Cryo-EM structure of the complete and ligand saturated insulin receptor ectodomain bioRxiv 679233; doi: https://doi.org 10.1101/679233
Backman, M., Flenkenthaler, F., Blutke, A., Dahlhoff, M., Ländström, E., Renner, S., Philippou-Massier, J., Krebs, S., Rathkolb, B., Prehn, C., Grzybek, M., Coskun, Ü., Rothe, M., Adamski, J., Hrabě de Angelis, M., Wanke, R., Fröhlich, T., Arnold, G.J., Blum, H., Wolf, E. Multi-omics insights into functional alterations of the liver in insulin deficient diabetes mellitus. Mol. Metab., 26, 30-44
Grzybek, M.; Palladini, A.; Alexaki, V. I.; Surma, M. A.; Simons, K.; Chavakis, T.; Klose, C. & Coskun, Ü. Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics. Molecular Metabolism doi: 10.1016/j.molmet.2019.01.009
Kourtzelis I, Li X, Mitroulis I, Grosser D, Kajikawa T, Wang B, Grzybek M, von Renesse J, Czogalla A, Troullinaki M, Ferreira A, Doreth C, Ruppova K, Chen LS, Hosur K, Lim JH, Chung KJ, Grossklaus S, Tausche AK, Joosten LAB, Moutsopoulos NM, Wielockx B, Castrillo A, Korostoff JM, Coskun Ü, Hajishengallis G, Chavakis T. DEL-1 promotes macrophage efferocytosis and clearance of inflammation. Nature Immunology 20, 40–49
2018
Brankatschk M, Gutmann T, Knittelfelder O, Palladini A, Prince E, Grzybek M, Brankatschk B, Shevchenko A, Coskun Ü, Eaton S. A Temperature-Dependent Switch in Feeding Preference Improves Drosophila Development and Survival in the Cold. Dev Cell. 47(2):257-259
Gutmann, T., Kim, K.H., Grzybek, M., Walz, T., Coskun, Ü. Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor. J Cell Biol. 217(5):1643-1649
Mitroulis, I., Ruppova, K., Wang, B., Chen, L.S., Grzybek, M., Grinenko, T., Eugster, A., Troullinaki, M., Palladini, A., Kourtzelis, I., Chatzigeorgiou, A., Schlitzer, A., Beyer, M., Joosten, L.A.B., Isermann, B., Lesche, M., Petzold, A., Simons, K., Henry, I., Dahl, A., Schultze, J.L., Wielockx, B., Zamboni, N., Mirtschink, P., Coskun, Ü., Hajishengallis, G., Netea, M.G., Chavakis, T. Modulation of myelopoiesis progenitors is an integral component of trained immunity. Cell 172, 147-161.e12
Toepfner, N., Herold, C., Otto, O., Rosendahl, P., Jacobi, A., Kraeter, M., Staechele, J., Menschner, L., Herbig, M., Ciuffreda, L., Ford-Cartwright, L., Grzybek, M., Coskun, Ü., Reithuber, E., Garriss, G., Mellroth, P., Henriques-Normark, B., Tregay, N., Suttorp, M., Bornhaeuser, M., Chilvers, E.R., Berner, R., Guck, J. Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood. eLife 7:e29213
2017
Anitei, M., Stange, C., Czupalla, C., Niehage, C., Schuhmann, K., Sala, P., Czogalla, A., Pursche, T., Coskun, Ü., Shevchenko, A., Hoflack, B. Spatiotemporal control of lipid conversion, actin-based mechanical forces, and curvature sensors during clathrin/AP-1-coated vesicle biogenesis. Cell Rep. 20, 2087-2099
Bilkova, E., Pleskot, R., Rissanen, S., Sun, S., Czogalla, A., Cwiklik, L., Róg, T., Vattulainen, I., Cremer, P.S., Jungwirth, P., Coskun, Ü. Calcium directly regulates phosphatidylinositol 4,5-Bbsphosphate headgroup conformation and recognition. J. Am. Chem. Soc. 139, 4019-4024
Blutke, A., Renner, S., Flenkenthaler, F., Backman, M., Haesner, S., Kemter, E., Ländström, E., Braun-Reichhart, C., Albl, B., Streckel, E., Rathkolb, B., Prehn, C., Palladini, A., Grzybek, M., Krebs, S., Bauersachs, S., Bähr, A., Brühschwein, A., Deeg, C.A., De Monte, E., Dmochewitz, M., Eberle, C., Emrich, D., Fux, R., Groth, F., Gumbert, S., Heitmann, A., Hinrichs, A.S., Keßler, B., Kurome, M., Leipig-Rudolph, M., Matiasek, K., Öztürk, H., Otzdorff, C., Reichenbach, M., Reichenbach, H.D., Rieger, A., Rieseberg, B., Rosati, M., Saucedo, M.N., Schleicher, A., Schneider, M.R., Simmet, K., Steinmetz, J., Übel, N., Zehetmaier, P., Jung, A., Adamski, J., Coskun, Ü., Hrabě de Angelis, M., Simmet, C., Ritzmann, M., Meyer-Lindenberg, A., Blum, H., Arnold, G.J., Fröhlich, T., Wanke, R., Wolf, E. The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes. Mol. Metab. 6, 931-940
Schuhmann, K., Srzentić, K., Nagornov, K.O., Thomas, H., Gutmann, T., Coskun, Ü., Tsybin, Y.O., Shevchenko, A. Monitoring membrane lipidome turnover by metabolic15N labeling and shotgun ultra-high-resolution orbitrap fourier transform mass spectrometry. Anal. Chem. 89, 12857-12865
Steringer, J.P., Lange, S., Čujová, S., Šachl, R., Poojari, C., Lolicato, F., Beutel, O., Müller, H.M., Unger, S., Coskun, Ü., Honigmann, A., Vattulainen, I., Hof, M., Freund, C., Nickel, W. Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components. eLife 6:e28985
2016
Klose, C., Coskun, Ü. Shotgun Lipidomics in der biomedizinischen und klinischen Forschung: Hochdurchsatzscreening. BIOspektrum 22, 617-619
Simons, K., Coskun, Ü. Membrane lipid galore. J. Mol. Biol. 428, 4737-4738
2015
Beutel, O., Roder, F., Birkholz, O., Rickert, C., Steinhoff, H., Grzybek, M., Coskun, Ü., Piehler, J. Two-dimensional trap for ultrasensitive quantification of transient protein interactions. ACS Nano 9, 9783-9791
Kaszuba, K., Grzybek, M., Orłowski, A., Danne, R., Róg, T., Simons, K., Coskun, Ü., Vattulainen, I. N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes. Proc. Natl. Acad. Sci. U.S.A. 112, 4334–4339
Lenoir, M., Grzybek, M., Majkowski, M., Rajesh, S., Kaur, J., Whittaker, S.B., Coskun, Ü., Overduin, M. Structural basis of dynamic membrane recognition by trans-Golgi network specific FAPP proteins. J. Mol. Biol. 427, 966-981
Luisoni, S., Suomalainen, M., Boucke, K., Tanner, L.B., Wenk, M.R., Guan, X.L., Grzybek, M., Coskun, Ü., Greber, U.F. Co-option of membrane wounding enables virus penetration into cells. Cell Host Microbe 18, 75-85
Sezgin, E., Gutmann, T., Buhl, T., Dirkx, R., Grzybek, M., Coskun, Ü., Solimena, M., Simons, K., Levental, I., Schwille, P. Adaptive lipid packing and bioactivity in membrane domains. PLoS ONE 10:e0123930
2014
Czogalla, A., Grzybek, M., Jones, W., Coskun, Ü. Validity and applicability of membrane model systems for studying interactions of peripheral membrane proteins with lipids. Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1841, 1049-1059
Gerl, M.J., Sachsenheimer, T., Grzybek, M., Coskun, Ü., Wieland, F.T., Brügger, B. Analysis of transmembrane domains and lipid modified peptides with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Anal. Chem. 86, 3722-3726
Grzybek, M., Gutmann, T., Coskun, Ü.
Functional role of membrane lipids in EGF receptor dynamics and regulation
(2014) Cell Membrane Nanodomains: From Biochemistry to Nanoscopy, pp. 41-58.
2012
Sezgin, E., Levental, I., Grzybek, M., Schwarzmann, G., Müller, V., Honigmann, A., Belov, V.N., Eggeling, C., Coskun, Ü., Simons, K., Schwille, P. Partitioning, diffusion, and ligand binding of raft lipid analogs in model and cellular plasma membranes. Biochim. Biophys. Acta 1818, 1777-1784
2011
Coskun, Ü., Grzybek, M., Drechsel, D., Simons, K. Regulation of human EGF receptor by lipids. Proc. Natl. Acad. Sci. U.S.A. 108, 9044-9048
Coskun, Ü., Simons, K. Cell membranes: The lipid perspective. Structure 19, 1543-1548
Lingwood, D., Binnington, B., Róg, T., Vattulainen, I., Grzybek, M., Coskun, Ü., Lingwood, C.A., Simons, K. Cholesterol modulates glycolipid conformation and receptor activity. Nat. Chem. Biol. 7, 260-262
2010
Coskun, Ü., Simons, K. Membrane rafting: from apical sorting to phase segregation. FEBS Lett. 584, 1685-1693
Lenoir, M., Coskun, Ü., Grzybek, M., Cao, X., Buschhorn, S.B., James, J., Simons, K., Overduin, M. Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains. EMBO Rep. 11, 279-284
Levental, I., Lingwood, D., Grzybek, M., Coskun, Ü., Simons, K. Palmitoylation regulates raft affinity for the majority of integral raft proteins. Proc. Natl. Acad. Sci. U.S.A. 107, 22050-22054
2009
Cao, X., Coskun, Ü., Rössle, M., Buschhorn, S.B., Grzybek, M., Dafforn, T.R., Lenoir, M., Overduin, M., Simons, K. Golgi protein FAPP2 tubulates membranes. Proc. Natl. Acad. Sci. U.S.A. 106, 21121-21125
Ohya, T., Miaczynska, M., Coskun, Ü., Lommer, B., Runge, A., Drechsel, D., Kalaidzidis, Y., Zerial, M. Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes. Nature 459, 1091-1097
2006
Müller, V., Lemker, T., Lingl, A., Weidner, C., Coskun, Ü., Grüber, G.
Bioenergetics of archaea: ATP synthesis under harsh environmental conditions
Journal of Molecular Microbiology and Biotechnology, 10 (2-4), pp. 167-180
2004
Chaban, Y.L., Coskun, Ü., Keegstra, W., Oostergetel, G.T., Boekema, E.J., Grüber, G.
Structural characterization of an ATPase active F1-/V 1-ATPase (α3β3EG) hybrid complex Journal of Biological Chemistry, 279 (46), pp. 47866-47870
Coskun, Ü., Chaban, Y.L., Lingl, A., Müller, V., Keegstra, W., Boekema, E.J., Grüber, G.
Structure and subunit arrangement of the A-type ATP synthase complex from the archaeon Methanococcus jannaschii visualized by electron microscopy
Journal of Biological Chemistry, 279 (37), pp. 38644-38648
Armbrüster, A., Svergun, D.I., Coskun, U., Juliano, S., Bailer, S.M., Grüber, G.
Structural analysis of the stalk subunit Vma5p of the yeast V-ATPase in solution
FEBS Letters, 570 (1-3), pp. 119-125
Coskun, U., Rizzo, V.F., Koch, M.H.J., Grüber, G.
Ligand-dependent structural changes in the V 1 ATPase from Manduca sexta
Journal of Bioenergetics and Biomembranes, 36 (3), pp. 249-256
Coskun, Ü., Radermacher, M., Müller, V., Ruiz, T., Grüber, G.
Three-dimensional organization of the archaeal A1-ATPase from methanosarcina mazei Gö1 Journal of Biological Chemistry, 279 (21), pp. 22759-22764
2003
Rizzo, V.F., Coskun, Ü., Radermacher, M., Ruiz, T., Armbrüster, A., Grüber, G.
Resolution of the V1 ATPase from Manduca sexta into subcomplexes and visualization of an ATPase-active A3B3EG complex by electron microscopy
Journal of Biological Chemistry, 278 (1), pp. 270-275
2002
Grüber, G., Godovac-Zimmermann, J., Link, T.A., Coskun, U., Rizzo, V.F., Betz, C., Bailer, S.M. Expression, purification, and characterization of subunit E, an essential subunit of the vacuolar ATPase Biochemical and Biophysical Research Communications, 298 (3), pp. 383-391
Coskun, U., Grüber, G., Koch, M.H.J., Godovac-Zimmermann, J., Lemker, T., Müller, V.M.
Cross-talk in the A 1-ATPase from Methanosarcina mazei Gö1 due to nucleotide binding Journal of Biological Chemistry, 277 (19), pp. 17327-17333
2001
Grüber, G., Svergun, D.I., Coskun, Ü., Lemker, T., Koch, M.H.J., Schägger, H., Müller, V.
Structural insights into the A1 ATPase from the archaeon, Methanosarcina mazei Gö1
Biochemistry, 40 (7), pp. 1890-1896
Schäfer, H.-J., Coskun, Ü., Eger, O., Godovac-Zimmermann, J., Wieczorek, H., Kagawa, Y., Grüber, G. 8-N3-3′-biotinyl-ATP, a novel monofunctional reagent: Differences in the F1- and V1-ATPases by means of the ATP analogue Biochemical and Biophysical Research Communications, 286 (5), pp. 1218-1227