Publications
An up-to-date list of all publications can be found here here!
Gopalakrishnan, J., Feistel, K., Friedrich, B.M., Grapin-Botton, A., Jurisch-Yaksi, N., Mass, E., Mick, D.U., Müller, R.U., May-Simera, H., Schermer, B., Schmidts, M., Walentek, P., Wachten, D. (2023) Emerging principles of primary cilia dynamics in controlling tissue organization and function. EMBO J. Sep 25:e113891. doi: 10.15252/embj.2023113891.
Beydag-Tasöz, B.S., Verner D’Costa, J., Hersemann, L., Lee, B.H., Luppino, F., Kim, Y.H., Zechner, C. and Grapin-Botton, A. (2023) Integration of transcriptional and imaging single-cell datasets links differentiation and morphogenetic dynamics of pancreatic endocrine progenitors. Developmental Cell S1534-5807(23)00366-0. doi: 10.1016/j.devcel.2023.07.019.
Beydag-Tasöz, B.S., Yennek, S. and Grapin-Botton, A. (2023) Towards a better understanding of diabetes mellitus using organoid models. Nat. Rev. Endocrinol. 19(4)232-248. doi: 10.1038/s41574-022-00797-x.
Grapin-Botton, A. and Kim, Y.H. (2022) Pancreas organoid models of development and regeneration. Development 149(20):dev201004. doi: 10.1242/dev.201004.
Katsumoto, K., Yennek, S., Chen, C., Delgadillo Silva, L.F., Traikov, S., Sever, D., Azad, A., Shan, J., Vainio, S., Ninov, N., Speier, S. and Grapin-Botton, A. (2022) Wnt4 is heterogeneously activated in maturing β-cells to control calcium signaling, metabolism and function. Nature Communications 13(1), 6255. doi: 10.1038/s41467-022-33841-5.
Keshara, R., Kim, Y.H. and Grapin-Botton, A. (2022) Organoid Imaging: Seeing Development and Function. Annu. Rev. Cell Dev. Biol. 38:447-466. doi: 10.1146/annurev-cellbio-120320-035146.
Tan TH, Liu J, Grapin-Botton A. (2022) Mapping and exploring the organoid state space using synthetic biology. Semin Cell Dev Biol. S1084-9521(22)00141-0. doi: 10.1016/j.semcdb.2022.04.015.
Grapin-Botton A, Ludwig B. (2022) Stem cell-derived β cells go in monkeys. Cell Stem Cell. 7;29(4):500-502. doi: 10.1016/j.stem.2022.03.010.
Nakamura, A., Wong, Y.F., Venturato, A., Michaut, M., Venkateswaran, S., Santra, M., Gonçalves, C., Larsen, M., Leuschner, M., Kim, Y.H., Brickman, J., Bradley, M. and Grapin-Botton, A. (2022) A long-term feeder-free culture of human pancreatic progenitors on fibronectin or matrix-free polymer potentiates β-cell differentiation. Stem Cell Reports, S2213-6711(22)00146-1. doi: 10.1016/j.stemcr.2022.03.013.
Lee, B.H., Seijo-Barandiaran, I., Grapin-Botton, A. (2022) Epithelial morphogenesis in organoids. Curr Opin Genet Dev. 72:30-37. doi: 10.1016/j.gde.2021.10.001. Review
Gonçalves, C.A., Larsen, M., Jung, S., Stratmann, J., Nakamura, A., Leuschner, M., Hersemann, L., Keshara,R., Perlman, S., Lundvall, L., Langhoff Thuesen, L., Juul Hare, K., Amit, I., Jørgensen, A., Kim, Y.H., del Sol, A., Grapin-Botton, A. (2021) A 3D system to model human pancreas development and its reference single cell transcriptome atlas reveal signaling pathways required for progenitor expansion. Nature Communications, 12(1):3144. doi: 10.1038/s41467-021-23295-6.
Flasse, L., Schewin, C. and Grapin-Botton A. (2021) Pancreas morphogenesis: Branching in and then out. Curr Top Dev Biol. 143:75-110. doi: 10.1016/bs.ctdb.2020.10.006. Review.
Lewis, A., Keshara, R., Kim, Y.H. and Grapin-Botton, A. (2020) Self-organization of organoids from endoderm-derived cells. J Mol Med (Berl). Nov 22. doi: 10.1007/s00109-020-02010-w. Review.
Borries, M., Barooji, Y.F., Yennek, S ., Grapin-Botton, A., Berg-Sørensen, K. and Oddershede, L. B. (2020) Quantification of Visco-Elastic Properties of a Matrigel for Organoid Development as a Function of Polymer Concentration. Frontiers in Physics 8, 475. https://doi.org/10.3389/fphy.2020.579168
Sever, D. and Grapin-Botton, A. (2020) Regeneration of the pancreas: proliferation and cellular conversion of surviving cells. Curr Opin Genet Dev. 64:84-93. doi: 10.1016/j.gde.2020.06.005. Review.
Katsumoto, K. and Grapin-Botton, A. (2020) Nutrients men-TOR β-Cells to Adulthood. Dev Cell. 54(2):140-141. doi: 10.1016/j.devcel.2020.06.028. Commentary.
Flasse, L., Yennek, S., Cortijo, C., Barandiaran, I.S., Kraus, M.R. and Grapin-Botton, A. (2020) Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity. Cell Rep. 31(8):107677. doi: 10.1016/j.celrep.2020.107677.
Huijbregts, L., Petersen, M.B.K., Berthault, C., Hansson, M., Aiello, V., Rachdi, L., Grapin-Botton, A., Honore, C., Scharfmann, R. (2019) Bromodomain and Extra Terminal Protein Inhibitors Promote Pancreatic Endocrine Cell Fate. Diabetes 68:761-773. doi: 10.2337/db18-0224.
Ramond, C., Beydag-Tasöz, B.S., Azad, A., van de Bunt, M., Petersen, M.B.K., Beer, N.L., Glaser, N., Berthault, C., Gloyn, A.L., Hansson, M., McCarthy, M., Honoré, C., Grapin-Botton, A.#, Scharfmann, R.#(2018) Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling. Development, 145(16). pii: dev165480. doi: 10.1242/dev.165480. # Shared last authorship
Dahl-Jensen, S.B., Yennek, S., Flasse, L., Larsen, H.L, Sever, D., Karremore, G., Novak, I., Sneppen, K. # and Grapin-Botton, A. # (2018) Deconstructing the principles of ductal network formation in the pancreas. PLoS Biol., 16(7):e2002842. doi: 10.1371/journal.pbio.2002842. # Shared last authorship
Petersen, N., Frimurer, T.M., Pedersen, M.T., Egerod, K.L., Wewer Albrechtsen, N.J., Holst, J.J., Grapin-Botton, A., Jensen, K.B. and Schwartz, T.W. (2018) Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine. Gastroenterology pii: S0016-5085(18)34666-3. doi: 10.1053/j.gastro.2018.06.039.
Petersen, M.B.K., Gonçalves,C.A.C., Kim, Y.H. and Grapin-Botton, A. (2018) Recapitulating and Deciphering Human Pancreas Development From Human Pluripotent Stem Cells in a Dish. Curr. Top. Dev. Biol. 129:143-190. doi: 10.1016/bs.ctdb.2018.02.009. Review.
Tsonkova, V.G., Sand, F.W., Wolf, X.A., Grunnet, L.G., Kirstine Ringgaard, A., Ingvorsen, C., Winkel, L., Kalisz, M., Dalgaard, K., Bruun, C., Fels, J.J., Helgstrand, C., Hastrup, S., Öberg, F.K., Vernet, E., Sandrini, M.P.B., Shaw, A.C., Jessen, C., Grønborg, M., Hald, J., Willenbrock, H., Madsen, D., Wernersson, R., Hansson, L., Jensen, J.N., Plesner, A., Alanentalo, T., Petersen, M.B.K., Grapin-Botton, A., Honoré, C., Ahnfelt-Rønne, J., Hecksher-Sørensen, J., Ravassard, P., Madsen, O.D., Rescan, C. and Frogne, T. (2018) The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates. Mol. Metab. 8:144-157. doi: 10.1016/j.molmet.2017.12.007.
Larsen, H.L., Martín-Coll, L., Nielsen, A.V., Wright, C.V.E., Trusina, A., Kim, Y.H. #, Grapin-Botton, A. # (2017) Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis. Nat Commun. 8:605. doi: 10.1038/s41467-017-00258-4. # Shared last authorship
Petersen, M.B.K., Azad, A., Ingvorsen, C., Hess, K., Hansson, M., Grapin-Botton, A.*, Honoré, C.* (2017) Single-Cell Gene Expression Analysis of a Human ESC Model of Pancreatic Endocrine Development Reveals Different Paths to β-Cell Differentiation. Stem Cell Reports 9:1246-1261. doi: 10.1016/j.stemcr.2017.08.009. * Equal contribution.
Dahl-Jensen, S., Grapin-Botton, A. (2017) The physics of organoids: a biophysical approach to understanding organogenesis. Development. 144:946-951. doi: 10.1242/dev.143693. Review.
Martin, D., Grapin-Botton, A. (2017) The Importance of REST for Development and Function of Beta Cells. Front Cell Dev Biol 5:12. doi: 10.3389/fcell.2017.00012. Review.
Grapin-Botton, A., Serup, P. (2017) Parsing the Pancreas. N. Engl. J. Med. 376:886-888. doi: 10.1056/NEJMcibr1616217. Review.
Larsen, H.L., Grapin-Botton, A. (2017) The molecular and morphogenetic basis of pancreas organogenesis. Semin Cell Dev Biol. 66:51-68. doi: 10.1016/j.semcdb.2017.01.005. Review.
Berclaz, C., Szlag, D., Nguyen, D., Extermann, J., Bouwens, A., Marchand, P.J., Nilsson, J., Schmidt-Christensen, A., Holmberg, D., Grapin-Botton, A., Lasser, T.. (2016) Label-free fast 3D coherent imaging reveals pancreatic islet micro-vascularization and dynamic blood flow. Biomed Opt Express. 7:4569-4580.
Grapin-Botton, A. (2016) Three-dimensional pancreas organogenesis models. Diabetes Obes Metab. Suppl 1:33-40. doi: 10.1111/dom.12720. Review.
Dahl-Jensen, S.B., Figueiredo -Larsen, M., Grapin-Botton, A.#, Sneppen, K#. (2016) Short-range growth inhibitory signals from the epithelium can drive non-stereotypic branching in the pancreas. Phys Biol. 13(1):016007. doi: 10.1088/1478-3975/13/1/016007. # Shared last authorship
Berclaz, C., Schmidt-Christensen, A., Szlag, D., Extermann, J., Hansen, L., Bouwens, A., Villiger, M., Goulley, J., Schuit, F., Grapin-Botton, A., Lasser, T., Holmberg, D. (2016) Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging. Diabetologia. 59(3):550-9. doi: 10.1007/s00125-015-3819-x.
Martin, D., Kim, Y.H., Sever, D., Mao, C.A., Haefliger, J.A.and Grapin-Botton, A. (2015) REST represses a subset of the pancreatic endocrine differentiation program. Dev Biol. 405:316-27. doi: 10.1016/j.ydbio.2015.07.002.
Ober, E.A. and Grapin-Botton, A. (2015) At new heights - endodermal lineages in development and disease. Development 142(11):1912-1917. doi: 10.1242/dev.121095.
Berclaz, C., Pache, C., Bouwens, A., Szlag, D., Lopez, A., Joosten, L., Ekim, S., Brom, M., Gotthardt, M., Grapin-Botton, A. and Lasser, T.. (2015) Combined Optical Coherence and Fluorescence Microscopy to assess dynamics and specificity of pancreatic beta-cell tracers. Sci Rep. 5:10385. doi: 10.1038/srep10385.
Grapin-Botton, A., Seymour, P.A. and Gradwohl, G. (2015) Pairing-up SOX to kick-start beta cell genesis. Diabetologia 58:859-61. doi: 10.1007/s00125-015-3539-2.
Kim, Y. H., List Larsen, H., Rué, P., Lemaire, L.A., Ferrer, J. and Grapin-Botton, A. (2015) Cell cycle-dependent differentiation dynamics balances growth and endocrine differentiation in the pancreas. PLoS Biology, 13:e1002111. doi: 10.1371/journal.pbio.1002111.
Lemaire, L.A, Goulley, J., Kim, Y.H., Carat, S., Jacquemin, P., Rougemont, J., Constam, D. and Grapin-Botton, A. (2015) Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal homeostasis. Development, 142:858-70. doi: 10.1242/dev.114611.
Rué, P., Kim, Y.H., List Larsen, H., Grapin-Botton, A., Martinez Arias, A. (2014) A framework for the analysis of symmetric and asymmetric divisions in developmental processes. BIORXIV/2014/010835,
Willet, S.G., Hale, M.A., Grapin-Botton, A., Magnuson, M.A., MacDonald, R.J., Wright, C.V. (2014) Dominant and context-specific control of endodermal organ allocation by Ptf1a. Development. 141(22):4385-94.
Greggio, C., De Franceschi, F. and Grapin-Botton, A. (2014) In Vitro-Produced Pancreas Organogenesis Models In Three Dimensions: Self-Organization From Few Stem Cells Or Progenitors. Stem Cells. 33:8-14.
Greggio, C., De Franceschi, F., Figueiredo-Larsen, M. and Grapin-Botton, A. (2014) In vitro pancreas organogenesis from dispersed mouse embryonic progenitors. J Vis Exp. 19;(89). doi: 10.3791/51725.
Hanotel, J., Bessodes, N., Thélie, A., Hedderich, M., Parain, K., Van Driessche, B., Brandão Kde, O., Kricha, S., Jorgensen, M.C., Grapin-Botton, A., Serup, P., Van Lint, C., Perron, M., Pieler, T., Henningfeld, K.A. and Bellefroid, E.J. (2014) The Prdm13 histone methyltransferase encoding gene is a Ptf1a-Rbpj downstream target that suppresses glutamatergic and promotes GABAergic neuronal fate in the dorsal neural tube. Dev Biol. 386:340-57.
Greggio, C., De Franceschi, F., Figueiredo-Larsen, M., Gobaa, S., Ranga, A., Semb, H., Lutolf, M. and Grapin-Botton, A. (2013) Artificial three-dimensional niches deconstruct pancreas development in vitro. Development, 140:4452-62. doi: 10.1242/dev.096628.
Kartikasari, A.E., Zhou, J.X., Kanji, M.S., Chan, D.N., Sinha, A., Grapin-Botton, A., Magnuson, M.A., Lowry, W.E. and Bhushan, A. (2013) The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation. EMBO J. 32:1393-408.
Qu, X., Afelik, S., Jensen, J.N., Bukys, M.A., Kobberup, S., Schmerr, M., Xiao, F., Nyeng, P., Veronica Albertoni, M., Grapin-Botton, A. and Jensen J. (2013) Notch-mediated post-translational control of Ngn3 protein stability regulates pancreatic patterning and cell fate commitment. Dev Biol. 376:1-12.
Cortijo, C., Gouzi, M., Tissir, F. and Grapin-Botton, A. (2012) Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis. Cell Reports 2:1593-606.
Serup, P., Gustavsen, C., Klein, T., Potter, L.A., Lin, R., Mullapudi, N., Wandzioch, E., Hines, A., Davis, A., Bruun, C., Engberg, N., Petersen, D.R., Peterslund, J.M., Macdonald, R.J., Grapin-Botton, A., Magnuson, M.A. and Zaret, K.S. (2012) Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice. Dis. Model Mech. 5(6):956-66.
Choi, E., Kraus, M.R.C., Lemaire L.A., Yoshimoto, M., Vemula, S, Potter, L.A., Manduchi, E., Stoeckert, C.J., Grapin-Botton, A. and Magnuson, M.A. (2012) Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells 30(10):2297-30.
Kraus, M.R. and Grapin-Botton, A. (2012) Patterning and shaping the endoderm in vivo and in culture. Curr Opin Genet Dev. 22(4):347-53.
Berclaz, C., Goulley, J., Villiger, M., Pache, C., Bouwens, A., Martin-Williams, E., Van de Ville, D., Davison, A.C., Grapin-Botton, A. and Lasser, T. (2012) Diabetes imaging-quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy. Biomed Opt Express 3(6):1365-80.
Shih, H.P., Kopp, J.L., Sandhu, M., Dubois, C.L., Seymour, P.A., Grapin-Botton, A. and Sander, M. (2012) A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation. Development 139(14):2488-99.
Thompson, N., Gésina, E., Scheinert, P., Bucher, P. and Grapin-Botton, A. (2012) RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors. Mol Cell Biol. 32(6):1189-99.
Boutant, M., Ramos, O.H., Tourrel-Cuzin, C., Movassat, J., Ilias, A., Vallois, D., Planchais, J., Pégorier, J.P., Schuit, F., Petit, P.X., Bossard, P., Maedler, K., Grapin-Botton, A. and Vasseur-Cognet, M. (2012) COUP-TFII Controls Mouse Pancreatic β-Cell Mass through GLP-1-β-Catenin Signaling Pathways. PLoS One 7(1):e30847.
R-C Kraus, M., Clauin, S., Pfister,Y., Di Maïo, M., Ulinski, T., Constam, D., Bellanné-Chantelot, C. and Grapin-Botton, A. (2011) Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associate with cystic renal dysplasia. Human Mutation 33(1):86-90.
Gouzi, M.; Kim, Y.H., Katsumoto, K., Johansson, K. and Grapin-Botton, A. (2011) Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development. Dev. Dyn. 240(3):589-604.
Villiger, M., Goulley, J., Martin-Williams, E.J., Grapin-Botton, A. and Lasser, T. (2010) Towards high resolution optical imaging of beta cells in vivo. Curr Pharm Des. 16:1595-608.
Bayha, E., Jørgensen, M.C., Serup, P. and Grapin-Botton, A. (2009) Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis. PLoS One 4:e5845.
Villiger, M., Goulley, J., Friedrich, M., Grapin-Botton, A., Meda, P., Lasser, T. and Leitgeb, R.A. (2009) In vivo imaging of endocrine islets with extended focus Optical Coherence Microscopy. Diabetologia 52:1599-607.
Grapin-Botton, A. (2008) Endoderm specification- In StemBook. http://www.stembook.org/
Johansson, K., Dursun, U., Jordan, N., Gu, G., Beermann, F., Gradwohl, G. and Grapin-Botton, A. (2007) Temporal control of Neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cells. Developmental Cell 12:457-65.
Grapin-Botton, A., Heimberg, H. and Lemaigre, F. (2007) The genetic programme of pancreatic beta-cells: basic science for the development of beta-cell therapy. Workshop on programming pancreatic beta-cells. EMBO Rep. 8:322-6.
Grapin-Botton, A. and Constam, D. (2012) Evolution of the mechanisms and molecular control of endoderm formation. Mech. Dev. 124:253-78.
Dessimoz, J., Opoka, R., Kordich, J.J., Grapin-Botton, A. and Wells, J.M. (2006) FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo. Mechanisms of Development, 123, 42-45.
Dessimoz, J. and Grapin-Botton, A. (2006) Pancreas development and cancer: Wnt/beta-catenin at issue... Cell Cycle. 5:7-10. I
Dessimoz, J., Bonnard, C., Huelsken, J. and Grapin-Botton, A. (2005) Pancreas-specific deletion of b-catenin reveals Wnt-dependent and Wnt-independent functions during development. Current Biology 15:1677-83.
Grapin-Botton, A. (2005) Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis. Int J Dev Biol. 49:335-47.
Grapin-Botton, A. (2005) Ductal cells of the pancreas. Int. J. Biochem. Cell Biol. 37:504-510.
Grapin-Botton, A. and Constam, D. (2004) Endoderm development. Gastrulation. Cold Spring Harbor Laboratory Press. Claudio Stern Editor.
Maya Kumar, Nathalie Jordan, Doug Melton and Anne Grapin-Botton (2003) Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. Dev. Biol. 259:109-22.
Johansson, K. and Grapin-Botton, A. (2002) Development and diseases of the pancreas. Clin. Genet. 62:14-23.
Grapin-Botton, A. (2002) Les étapes du développement du pancréas: des pistes pour le traitement du diabète. Médecine/Sciences 18:467-473.
Ladjali-Mohammedi, K., Grapin-Botton, A., Bonnin, M.A., Le Douarin, N.M. (2001) Distribution of HOX genes in the chicken genome reveals a new segment of conservation between human and chicken. Cytogenet Cell Genet. 92:157-61.
Grapin-Botton, A. , Majithia, A. R. and Melton, D.M. (2001). Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev., 15, 444-454.
Grapin-Botton, A. and Melton, D.M. (2000). Endoderm development: from patterning to organogenesis. Trends in Genetics 16, 124-130.
Grapin-Botton, A., Cambronero, F., Weiner, H., Bonnin, M.-A., Puelles, L. and Le Douarin, N.M. (1999). Patterning signals acting in the spinal cord override the organizing activity of the isthmus. Mech. Dev. 84, 41-53.
Couly, G., Grapin-Botton, A., Coltey, P., Ruhin, B. and Le Douarin, N.M. (1998). Determination of the identity of the derivatives of the cephalic neural crest: incompatibility between Hox-gene expression and lower jaw development. Development 125, 3445-59.
Nataf, V., Grapin-Botton, A., Champeval, D., Amemiya, A.,Yanagisawa, A. and N.M. Le Douarin, N.M. (1998). The expression patterns of endothelin-A receptors and endothelin 1 in the avian embryo. Mech. Dev. 75, 145-49.
Mager, A-M., Grapin-Botton, A., Ladjali, K., Meyer, D., Wolff, C-M., Stiegler, P., Bonnin, M.-A., and Remy, P. (1998). The avian Fli gene is specifically expressed in a subset of neural crest cells giving rise to mesenchyme. Int. J. Dev. Biol. 42, 561-72.
Grapin-Botton, A., Bonnin, M.-A. . Sieweke, M. and Le Douarin, N.M. (1998) Defined concentrations of a posteriorizing signal are critical for MafB/Kreisler segmental expression in the hindbrain. Development, 125, 1173-1181.
Eichmann, A., Sieweke, M., Grapin-Botton, A., Kelly, L., Graf, T. and Le Douarin, N.M. (1997) The expression pattern of MafB/Kr gene in birds and mice reveals that the kreisler phenotype does not represent a null mutant. Mech. Dev. 65, 111-122.
Le Douarin, N.M. and Grapin-Botton, A. (1997) Contrôle génétique du développement du rhombencéphale par les gènes Hox étudié chez l'embryon d'oiseau par la méthode des chimères caille-poulet. C.R. Soc. Biol. 191, 29-42.
Grapin-Botton, A., Bonnin, M.-A. and Le Douarin, N.M. (1997). Hox gene induction in the neural tube depends on three parameters: competence, signal supply and paralogue group. Development 124 (4), 849-859.
Couly, G., Grapin-Botton, A., Coltey, P. and Le Douarin, N.M. (1996). The regeneration of the cephalic neural crest, a problem revisited: the regenerating cells originate from the contralateral or from the anterior and posterior neural fold. Development 122, 3393-3407.
Le Douarin, N.M., Grapin-Botton, A. and Catala, M. (1996). Patterning of the neural primordium in the avian embryo. Seminars in Cell and Dev. Biol. 7, 157-167.
Grapin-Botton, A., Bonnin, M.-A., McNaughton, L.A., Krumlauf, R. and Le Douarin, N.M. (1995). Plasticity of transposed rhombomeres: Hox gene induction is correlated with phenotypic modifications. Development 121, 2707-2721.