Publications
Holt RIG, DeVries JH, Hess-Fischl A, Hirsch IB, Kirkman MS, Klupa T, Ludwig B, Nørgaard K, Pettus J, Renard E, Skyler JS, Snoek FJ, Weinstock RS, Peters AL. Correction to: The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2022 Jan;65(1):255. doi: 10.1007/s00125-021-05600-6. PMID: 34851428
Schubert U, Cohrs C, Kemter E, Ludwig B. 402.8: Neonatal porcine Pseudo-Islets - A Standardized and Scalable Source for Islet Encapsulation? Transplantation. 2021 Dec 1;105(12S1):S30. doi: 10.1097/01.tp.0000804456.07899.3f. PMID: 34908341 N
Holt RIG, DeVries JH, Hess-Fischl A, Hirsch IB, Kirkman MS, Klupa T, Ludwig B, Nørgaard K, Pettus J, Renard E, Skyler JS, Snoek FJ, Weinstock RS, Peters AL. The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2021 Dec;64(12):2609-2652. doi: 10.1007/s00125-021-05568-3. PMID: 34590174 Fr
Coppin E, Sundarasetty BS, Rahmig S, Blume J, Verheyden NA, Bahlmann F, Ravens S, Schubert U, Schmid J, Ludwig S, Geissler K, Guntinas-Lichius O, von Kaisenberg C, Groten T, Platz A, Naumann R, Ludwig B, Prinz I, Waskow C, Krueger A. Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7. Leukemia. 2021 Dec;35(12):3561-3567. doi: 10.1038/s41375-021-01259-5.PMID: 33976371
Steenblock C, Schwarz PEH, Ludwig B, Linkermann A, Zimmet P, Kulebyakin K, Tkachuk VA, Markov AG, Lehnert H, de Angelis MH, Rietzsch H, Rodionov RN, Khunti K, Hopkins D, Birkenfeld AL, Boehm B, Holt RIG, Skyler JS, DeVries JH, Renard E, Eckel RH, Alberti KGMM, Geloneze B, Chan JC, Mbanya JC, Onyegbutulem HC, Ramachandran A, Basit A, Hassanein M, Bewick G, Spinas GA, Beuschlein F, Landgraf R, Rubino F, Mingrone G, Bornstein SR. COVID-19 and metabolic disease: mechanisms and clinical management. Lancet Diabetes Endocrinol. 2021 Nov;9(11):786-798. doi: 10.1016/S2213-8587(21)00244-8. Epub 2021 Oct 4. PMID: 34619105
Holt RIG, DeVries JH, Hess-Fischl A, Hirsch IB, Kirkman MS, Klupa T, Ludwig B, Nørgaard K, Pettus J, Renard E, Skyler JS, Snoek FJ, Weinstock RS, Peters AL. The Management of Type 1 Diabetes in Adults. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2021 Nov;44(11):2589-2625. doi: 10.2337/dci21-0043. Epub 2021 Sep 30. PMID: 34593612
Kemter E, Müller A, Neukam M, Ivanova A, Klymiuk N, Renner S, Yang K, Broichhagen J, Kurome M, Zakhartchenko V, Kessler B, Knoch KP, Bickle M, Ludwig B, Johnsson K, Lickert H, Kurth T, Wolf E, Solimena M. Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2107665118. doi: 10.1073/pnas.2107665118. PMID: 34508004
Steenblock C, Richter S, Berger I, Barovic M, Schmid J, Schubert U, Jarzebska N, von Mässenhausen A, Linkermann A, Schürmann A, Pablik J, Dienemann T, Evert K, Rodionov RN, Semenova NY, Zinserling VA, Gainetdinov RR, Baretton G, Lindemann D, Solimena M, Ludwig B, Bornstein SR. Viral infiltration of pancreatic islets in patients with COVID-19. Nat Commun. 2021 Jun 10;12(1):3534. doi: 10.1038/s41467-021-23886-3. PMID: 34112801
Kögel J, Thiersch S, Ludwig B, Seissler J, Marckmann G. What does it take to consent to islet cell xenotransplantation?: Insights from an interview study with type 1 diabetes patients and review of the literature. BMC Med Ethics. 2021 Apr 1;22(1):37. doi: 10.1186/s12910-021-00607-5. PMID: 33794874
Bornstein SR, Rubino F, Ludwig B, Rietzsch H, Schwarz PEH, Rodionov RN, Khunti K, Hopkins D, Birkenfeld AL, Boehm B, Amiel S, Holt RIG, Skyler JS, DeVries JH, Renard E, Eckel RH, Zimmet P, Alberti KG, Geloneze B, Chan JC, Mbanya JC, Onyegbutulem HC, Ramachandran A, Basit A, Hassanein M, Spinas GA, Beuschlein F, Mingrone G. Consequences of the COVID-19 pandemic for patients with metabolic diseases. Nat Metab. 2021 Mar;3(3):289-292. doi: 10.1038/s42255-021-00358-y. PMID: 33633407
Everwien H, Keshi E, Hillebrandt KH, Ludwig B, Weinhart M, Tang P, Beierle AS, Napierala H, Gassner JM, Seiffert N, Moosburner S, Geisel D, Reutzel-Selke A, Strücker B, Pratschke J, Haep N, Sauer IM. Engineering an endothelialized, endocrine Neo-Pancreas: Evaluation of islet functionality in an ex vivo model. Acta Biomater. 2020 Nov;117:213-225. doi: 10.1016/j.actbio.2020.09.022. Epub 2020 Sep 16. PMID: 32949822
Bornstein SR, Malyukov M, Heller C, Ziegler CG, Ruiz-Babot G, Schedl A, Ludwig B, Steenblock C. New Horizons: Novel Adrenal Regenerative Therapies. J Clin Endocrinol Metab. 2020 Sep 1;105(9):3103-7. doi: 10.1210/clinem/dgaa438. PMID: 32629476
Bornstein SR, Zimmet P, Rubino F, Ludwig B. Management of diabetes in patients with COVID-19 - Authors' reply. Lancet Diabetes Endocrinol. 2020 Aug;8(8):669-670. doi: 10.1016/S2213-8587(20)30223-0. PMID: 32707113
Bornstein SR, Rubino F, Khunti K, Mingrone G, Hopkins D, Birkenfeld AL, Boehm B, Amiel S, Holt RI, Skyler JS, DeVries JH, Renard E, Eckel RH, Zimmet P, Alberti KG, Vidal J, Geloneze B, Chan JC, Ji L, Ludwig B. Practical recommendations for the management of diabetes in patients with COVID-19. Lancet Diabetes Endocrinol. 2020 Jun;8(6):546-550. doi: 10.1016/S2213-8587(20)30152-2. Epub 2020 Apr 23. PMID: 32334646
Ludwig B, Wolf E, Schönmann U, Ludwig S. Large Animal Models of Diabetes. Methods Mol Biol. 2020;2128:115-134. doi: 10.1007/978-1-0716-0385-7_9. PMID: 32180190
Goldman O, Puchinsky D, Durlacher K, Sancho R, Ludwig B, Kugelmeier P, Heller C, Kunicher N, Bornstein SR, Treves AJ. Lung Based Engineered Micro-Pancreas Sustains Human Beta Cell Survival and Functionality. Horm Metab Res. 2019 Dec;51(12):805-811. doi: 10.1055/a-1041-3305. Epub 2019 Dec 11. PMID: 31826275
Duin S, Schütz K, Ahlfeld T, Lehmann S, Lode A, Ludwig B, Gelinsky M. 3D
Bioprinting of Functional Islets of Langerhans in an Alginate/Methylcellulose
Hydrogel Blend. Adv Healthc Mater. 2019 Apr;8(7):e1801631. doi:
10.1002/adhm.201801631. Epub 2019 Mar 5. PubMed PMID: 30835971.
Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A,
Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U,
Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG,
Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G,
D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A. Report of
the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. Transplantation.
2018 Aug;102(8):1223-1229. doi: 10.1097/TP.0000000000002217. PubMed PMID:
29781950.
Evron Y, Colton CK, Ludwig B, Weir GC, Zimermann B, Maimon S, Neufeld T,
Shalev N, Goldman T, Leon A, Yavriyants K, Shabtay N, Rozenshtein T, Azarov D,
DiIenno AR, Steffen A, de Vos P, Bornstein SR, Barkai U, Rotem A. Long-term
viability and function of transplanted islets macroencapsulated at high density
are achieved by enhanced oxygen supply. Sci Rep. 2018 Apr 25;8(1):6508. doi:
10.1038/s41598-018-23862-w. PubMed PMID: 29695723; PubMed Central PMCID:
PMC5917036.
Balyura M, Gelfgat E, Steenblock C, Androutsellis-Theotokis A, Ruiz-Babot G,
Guasti L, Werdermann M, Ludwig B, Bornstein T, Schally AV, Brennand A, Bornstein
SR. Expression of progenitor markers is associated with the functionality of a
bioartificial adrenal cortex. PLoS One. 2018 Mar 29;13(3):e0194643. doi:
10.1371/journal.pone.0194643. eCollection 2018. PubMed PMID: 29596439; PubMed
Central PMCID: PMC5875767.
Rickels MR, Stock PG, de Koning EJP, Piemonti L, Pratschke J, Alejandro R,
Bellin MD, Berney T, Choudhary P, Johnson PR, Kandaswamy R, Kay TWH, Keymeulen B,
Kudva YC, Latres E, Langer RM, Lehmann R, Ludwig B, Markmann JF, Marinac M,
Odorico JS, Pattou F, Senior PA, Shaw JAM, Vantyghem MC, White S. Defining
outcomes for β-cell replacement therapy in the treatment of diabetes: a consensus
report on the Igls criteria from the IPITA/EPITA opinion leaders workshop.
Transpl Int. 2018 Apr;31(4):343-352. doi: 10.1111/tri.13138. Review. PubMed PMID:
29453879; PubMed Central PMCID: PMC5867272.
Simeonovic CJ, Popp SK, Starrs LM, Brown DJ, Ziolkowski AF, Ludwig B,
Bornstein SR, Wilson JD, Pugliese A, Kay TWH, Thomas HE, Loudovaris T, Choong FJ,
Freeman C, Parish CR. Loss of intra-islet heparan sulfate is a highly sensitive
marker of type 1 diabetes progression in humans. PLoS One. 2018 Feb
7;13(2):e0191360. doi: 10.1371/journal.pone.0191360. eCollection 2018. PubMed
PMID: 29415062; PubMed Central PMCID: PMC5802856.
Balyura, M., Gelfgat, E., Ullmann, E., Ludwig, B., Barnea, E.R., Bornstein, S.R., PreImplantation factor (PIF*) regulates stress-induced adrenal steroidogenesis and anti-inflammatory cytokines: Potential application for bioartificial adrenal transplant. Horm. Metab. Res., DOI: 10.1055/s-0043-120064 (2017)
Cohrs, C.M., Chen, C., Jahn, S., Stertmann, J., Chmelova, H., Weitz, J., Bähr, A., Klymiuk, N., Steffen, A., Ludwig, B., Kamvissi, V., Wolf, E., Bornstein, S.R., Solimena, M., Speier, S., Vessel network architecture of adult human islets promotes distinct cell-cell interactions in situ and is altered after transplantation. Endocrinology 158, 1-13 (2017)
Ludwig, B., Ludwig, S., Steffen, A., Knauf, Y., Zimerman, B., Heinke, S., Lehmann, S., Schubert, U., Schmid, J., Bleyer, M., Schoenmann, U., Colton, C.K., Bonifacio, E., Solimena, M., Reichel, A., Schally, A.V., Rotem, A., Barkai, U., Grinberg-Rashi, H., Kaup, F., Avni, Y., Jones, P., Bornstein, S.R., Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proc. Natl. Acad. Sci. U.S.A. 114, 11745-11750 (2017)
Steffen, A., Kiss, T., Schmid, J., Schubert, U., Heinke, S., Lehmann, S., Bornstein, S.R., Ludwig, B., Ludwig, S., Production of high-quality islets from goettingen minipigs: Choice of organ preservation solution, donor pool, and optimal cold ischemia time. Xenotransplantation 24:e12284 (2017)
Gruetzmann, R., Ludwig, B., Weitz, J., Ludwig, S., Totale Pankreatektomie und Isletautotransplantation bei einem Kind mit chronisch rezidivierender Pankreatitis. Zentralbl. Chir. 141, 17-20 (2016)
Heinke, S., Ludwig, B., Schubert, U., Schmid, J., Kiss, T., Steffen, A., Bornstein, S.R., Ludwig, S., Diabetes induction by total pancreatectomy in minipigs with simultaneous splenectomy: A feasible approach for advanced diabetes research. Xenotransplantation 23, 405-413 (2016)
Kourtzelis, I., Kotlabova, K., Lim, J.H., Mitroulis, I., Ferreira, A., Chen, L., Gercken, B., Steffen, A., Kemter, E., Klotzsche-von Ameln, A., Waskow, C., Hosur, K., Chatzigeorgiou, A., Ludwig, B., Wolf, E., Hajishengallis, G., Chavakis, T., Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation. Thromb. Haemost. 115, 781-788 (2016)
Markmann, J.F., Bartlett, S.T., Johnson, P., Korsgren, O., Hering, B.J., Scharp, D., Kay, T.W., Bromberg, J., Odorico, J.S., Weir, G.C., Bridges, N.D., Kandaswamy, R., Stock, P., Friend, P., Gotoh, M., Cooper, D.K., Park, C.G., OʼConnell, P.J., Stäbler, C., Matsumoto, S., Ludwig, B., Choudhary, P., Khovatchev, B., Rickels, M.R., Sykes, M., Wood, K., Kraemer, K., Hwa, A., Stanley, E., Ricordi, C., Zimmerman, M., Greenstein, J., Montanya, E., Otonkoski, T., Executive summary of IPITA-TTS opinion leaders report on the future of β-cell replacement. Transplantation 100, E25-E31 (2016)
Morozov, V.A., Ludwig, S., Ludwig, B., Rotem, A., Barkai, U., Bornstein, S.R., Denner, J., Islet cell transplantation from Gottingen minipigs to cynomolgus monkeys: Analysis of virus safety. Xenotransplantation 23, 320-327 (2016)
Struecker, B., Ludwig, S., Schmelzle, M., Ludwig, B., Cell transplantation for regeneration and function recovery before and after oncological resections. Onkologe 22, 478-487 (2016)
Balyura, M., Gelfgat, E., Ehrhart-Bornstein, M., Ludwig, B., Gendler, Z., Barkai, U., Zimerman, B., Rotem, A., Block, N.L., Schally, A.V., Bornstein, S.R. Transplantation of bovine adrenocortical cells encapsulated in alginate. Proc. Natl. Acad. Sci. U.S.A. 112, 2527-2532 (2015)
Catar, R.A., Müller, G., Brandt, A., Langbein, H., Brunssen, C., Goettsch, C., Frenzel, A., Hofmann, A., Goettsch, W., Steinbronn, N., Strasser, R.H., Schubert, U., Ludwig, B., Bornstein, S.R., Morawietz, H., Increased gene expression of the cardiac endothelin system in obese mice. Horm. Metab. Res. 47, 509-515 (2015)
Ehehalt, F., Sturm, D., Rösler, M., Distler, M., Weitz, J., Kersting, S., Ludwig, B., Schwanebeck, U., Saeger, H.-D., Solimena, M., Grützmann, R., Blood glucose homeostasis in the course of partial pancreatectomy - evidence for surgically reversible diabetes induced by cholestasis. PLoS ONE 10:e0134140 (2015)
Evron, Y., Zimermann, B., Ludwig, B., Barkai, U., Colton, C.K., Weir, G.C., Arieli, B., Maimon, S., Shalev, N., Yavriyants, K., Goldman, T., Gendler, Z., Eizen, L., Vardi, P., Bloch, K., Barthel, A., Bornstein, S.R., Rotem, A., Oxygen supply by photosynthesis to an implantable islet cell device. Horm. Metab. Res. 47, 24-30 (2015)
Ludwig, B., Reichel, A., Kruppa, A., Ludwig, S., Steffen, A., Weitz, J., Bornstein, S.R., Islet transplantation at the Dresden diabetes center: five years' experience. Horm. Metab. Res. 47, 4-8 (2015)
Ludwig, B., Ludwig, S., Transplantable bioartificial pancreas devices: Current status and future prospects. Langenbecks Arch. Surg. 400, 531-540 (2015)
Ludwig, B., Bioartifizielles Pankreas durch Inselzellverkapselung. Diabetologe 11, 558-567 (2015)
Reichart, B., Niemann, H., Chavakis, T., Denner, J., Jaeckel, E., Ludwig, B., Marckmann, G., Schnieke, A., Schwinzer, R., Seissler, J., Tönjes, R.R., Klymiuk, N., Wolf, E., Bornstein, S.R., Xenotransplantation of porcine islet cells as a potential option for the treatment of type 1 diabetes in the future. Horm. Metab. Res. 47, 31-35 (2015)
Ludwig, B., Barthel, A., Reichel, A., Block, N.L., Ludwig, S., Schally, A.V., Bornstein, S.R., Modulation of the pancreatic islet-stress axis as a novel potential therapeutic target in diabetes mellitus. Vitam. Horm. 95, 195-222 (2014)
Barkai, U., Weir, G.C., Colton, C.K., Ludwig, B., Bornstein, S.R., Brendel, M.D., Neufeld, T.P., Bremer, C., Leon, A., Evron, Y., Yavriyants, K., Azarov, D., Zimermann, B., Maimon, S., Shabtay, N., Balyura, M., Rozenshtein, T., Vardi, P., Bloch, K., de Vos, P., Rotem, A., Enhanced oxygen supply improves islet viability in a new bioartificial pancreas. Cell Transplant. 22, 1463-1476 (2013)
Ludwig, B., Reichel, A., Steffen, A., Zimerman, B., Schally, A.V., Block, N.L., Colton, C.K., Ludwig, S., Kersting, S., Bonifacio, E., Solimena, M., Gendler, Z., Rotem, A., Barkai, U., Bornstein, S.R., Transplantation of human islets without immunosuppression. Proc. Natl. Acad. Sci. U.S.A. 110, 19054-19058 (2013)
Neufeld, T.P., Ludwig, B., Barkai, U., Weir, G.C., Colton, C.K., Evron, Y., Balyura, M., Yavriyants, K., Zimermann, B., Azarov, D., Maimon, S., Shabtay, N., Rozenshtein, T., Lorber, D., Steffen, A., Willenz, U., Bloch, K., Vardi, P., Taube, R., de Vos, P., Lewis, E.C., Bornstein, S.R., Rotem, A., The efficacy of an immunoisolating membrane system for islet xenotransplantation in minipigs. PLoS ONE 8:e70150 (2013)
Phieler, J., Chung, K.-J., Chatzigeorgiou, A., Klotzsche-von Ameln, A., Garcia-Martin, R., Sprott, D., Moisidou, M., Tzanavari, T., Ludwig, B., Baraban, E., Ehrhart-Bornstein, M., Bornstein, S.R., Mziaut, H., Solimena, M., Karalis, K.P., Economopoulou, M., Lambris, J.D., Chavakis, T., The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance. J. Immunol. 191, 4367-4374 (2013)
Reichel, A., Rietzsch, H., Ludwig, B., Röthig, K., Moritz, A., Bornstein, S.R., Self-adjustment of insulin dose using graphically depicted self-monitoring of blood glucose measurements in patients with type 1 diabetes mellitus. J. Diabetes Sci. Technol. 7, 156-162 (2013)
Schubert, U., Schmid, J., Lehmann, S., Zhang, X.Y., Morawietz, H., Block, N.L., Kanczkowski, W., Schally, A.V., Bornstein, S.R., Ludwig, B., Transplantation of pancreatic islets to adrenal gland is promoted by agonists of growth-hormone-releasing hormone. Proc. Natl. Acad. Sci. U.S.A. 110, 2288-2293 (2013)
Ludwig, B., Rotem, A., Schmid, J., Weir, G.C., Colton, C.K., Brendel, M.D., Neufeld, T.P., Block, N.L., Yavriyants, K., Steffen, A., Ludwig, S., Chavakis, T., Reichel, A., Azarov, D., Zimmermann, B., Maimon, S., Balyura, M., Rozenshtein, T., Shabtay, N., Vardi, P., Bloch, K., de Vos, P., Schally, A.V., Bornstein, S.R., Barkai, U., Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc. Natl. Acad. Sci. U.S.A. 109, 5022-5027 (2012)
Uhlmann, D., Weber, T., Ludwig, S., Ludwig, B., Bartels, M., Hauss, J., Jonas, S., Witzigmann, H., Long-term outcome of conversion to sirolimus monotherapy after liver transplant. Exp. Clin. Transplant. 10, 30-38 (2012)
Ludwig, B., Bergstermann, A., Priesack, E., Flessa, H., Modelling of crop yields and N2O emissions from silty arable soils with differing tillage in two long-term experiments. Soil Tillage Res. 112, 114-121 (2011)
Ludwig, B., Jäger, N., Priesack, E., Flessa, H., Application of the DNDC model to predict N2O emissions from sandy arable soils with differing fertilization in a long-term experiment. J. Plant Nutr. Soil Sci. 174, 350-358 (2011)
Schmid, J., Ludwig, B., Schally, A.V., Steffen, A., Ziegler, C.G., Block, N.L., Koutmani, Y., Brendel, M.D., Karalis, K.P., Simeonovic, C.J., Licinio, J., Ehrhart-Bornstein, M., Bornstein, S.R., Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11beta-hydroxysteroid dehydrogenase. Proc. Natl. Acad. Sci. U.S.A. 108, 13722-13727 (2011)
Steffen, A., Ludwig, B., Krautz, C., Bornstein, S., Solimena, M., Functional assessment of automatically sorted pancreatic islets using large particle flow cytometry. Islets 3, 267-270 (2011)
Ziegler, C.G., Langbein, H., Krug, A.W., Ludwig, B., Eisenhofer, G., Ehrhart-Bornstein, M., Bornstein, S.R., Direct effect of dehydroepiandrosterone sulfate (DHEAS) on PC-12 cell differentiation processes. Mol. Cell. Endocrinol. 336, 149-155 (2011)
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