Nov 13, 2019; Talk
Breaking the bounds of imaging in label-free nanoscopy, micro-endoscopy and biomedical sensing
Imaging systems as well as human vision system have limited capability for separation of spatial features and this information can also be extracted only from depth limited range. The reasons to the resolution and depth of focus limitations are related to the effect of diffraction i.e. the finite dimensions of the imaging optics as well as the geometry of the sensor. The projection of wavelength dependent codes can enhance the resolution of collected light in micro-endoscopy cases. This concept of wavelength multiplexing super resolved imaging can also be applied for imaging through biological scattering medium such as biological tissues and liquids as blood. The projected light patterns are sent via laser-based illumination fiber while the light collection is performed via ultra-thin multi-core imaging fiber-based endoscopes. Resolution limits in microscopy related approaches can go much below sub-wavelength bound using label-free configurations involving time multiplexing (time dependent light collection) based upon label-free non-static nano-particles either moving in uncontrolled Brownian motion or being manipulated with light. Many biomedical parameters like the estimation of heart beats (rate and sound), respiration (rate and sound), blood pressure and more can be measured remotely and simultaneously with one photonic technological sensing platform. The proposed technique is based on illuminating a light scattering surface (human skin) with a laser.