Publikationen
Wagner R, Eckstein SS, Yamazaki H, Gerst F, Machann J, Jaghutriz BA, Schürmann A, Solimena M, Singer S, Königsrainer A, Birkenfeld AL, Häring HU, Fritsche A, Ullrich S, Heni M. Metabolic implications of pancreatic fat accumulation. Nat Rev Endocrinol. 2022 Jan;18(1):43-54. doi: 10.1038/s41574-021-00573-3. Epub 2021 Oct 20PMID: 34671102
Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV Jr, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF. Publisher Correction: An open-access volume electron microscopy atlas of whole cells and tissues. Nature. 2021 Nov;599(7885):E5. doi: 10.1038/s41586-021-04132-8.PMID: 34732896
Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV Jr, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF. An open-access volume electron microscopy atlas of whole cells and tissues. Nature. 2021 Nov;599(7883):147-151. doi: 10.1038/s41586-021-03992-4. Epub 2021 Oct 6.PMID: 34616045
Sánchez-Archidona AR, Cruciani-Guglielmacci C, Roujeau C, Wigger L, Lallement J, Denom J, Barovic M, Kassis N, Mehl F, Weitz J, Distler M, Klose C, Simons K, Ibberson M, Solimena M, Magnan C, Thorens B. Plasma triacylglycerols are biomarkers of β-cell function in mice and humans. Mol Metab. 2021 Oct 9;54:101355. doi: 10.1016/j.molmet.2021.101355. Online ahead of print. PMID: 34634522
Kemter E, Müller A, Neukam M, Ivanova A, Klymiuk N, Renner S, Yang K, Broichhagen J, Kurome M, Zakhartchenko V, Kessler B, Knoch KP, Bickle M, Ludwig B, Johnsson K, Lickert H, Kurth T, Wolf E, Solimena M. Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2107665118. doi: 10.1073/pnas.2107665118. PMID: 34508004
Wigger L, Barovic M, Brunner AD, Marzetta F, Schöniger E, Mehl F, Kipke N, Friedland D, Burdet F, Kessler C, Lesche M, Thorens B, Bonifacio E, Legido-Quigley C, Barbier Saint Hilaire P, Delerive P, Dahl A, Klose C, Gerl MJ, Simons K, Aust D, Weitz J, Distler M, Schulte AM, Mann M, Ibberson M, Solimena M. Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes. Nat Metab. 2021 Jun 28. doi: 10.1038/s42255-021-00420-9. Online ahead of print. PMID: 34183850
Steenblock C, Richter S, Berger I, Barovic M, Schmid J, Schubert U, Jarzebska N, von Mässenhausen A, Linkermann A, Schürmann A, Pablik J, Dienemann T, Evert K, Rodionov RN, Semenova NY, Zinserling VA, Gainetdinov RR, Baretton G, Lindemann D, Solimena M, Ludwig B, Bornstein SR. Viral infiltration of pancreatic islets in patients with COVID-19. Nat Commun. 2021 Jun 10;12(1):3534. doi: 10.1038/s41467-021-23886-3. PMID: 34112801
Hu M, Cebola I, Carrat G, Jiang S, Nawaz S, Khamis A, Canouil M, Froguel P, Schulte A, Solimena M, Ibberson M, Marchetti P, Cardenas-Diaz FL, Gadue PJ, Hastoy B, Almeida-Souza L, McMahon H, Rutter GA. Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion. Cell Rep. 2021 Mar 16;34(11):108881. doi: 10.1016/j.celrep.2021.108881. PMID: 33730570
Müller A, Schmidt D, Xu CS, Pang S, D'Costa JV, Kretschmar S, Münster C, Kurth T, Jug F, Weigert M, Hess HF, Solimena M. 3D FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse β cells. J Cell Biol. 2021 Feb 1;220(2):e202010039. doi: 10.1083/jcb.202010039. PMID: 33326005
Hazini A, Dieringer B, Pryshliak M, Knoch KP, Heimann L, Tolksdorf B, Pappritz K, El-Shafeey M, Solimena M, Beling A, Kurreck J, Klingel K, Fechner H. miR-375- and miR-1-Regulated Coxsackievirus B3 Has No Pancreas and Heart Toxicity But Strong Antitumor Efficiency in Colorectal Carcinomas. Hum Gene Ther. 2021 Feb;32(3-4):216-230. doi: 10.1089/hum.2020.228. Epub 2021 Jan 22. PMID: 33481658
Marselli L, Piron A, Suleiman M, Colli ML, Yi X, Khamis A, Carrat GR, Rutter GA, Bugliani M, Giusti L, Ronci M, Ibberson M, Turatsinze JV, Boggi U, De Simone P, De Tata V, Lopes M, Nasteska D, De Luca C, Tesi M, Bosi E, Singh P, Campani D, Schulte AM, Solimena M, Hecht P, Rady B, Bakaj I, Pocai A, Norquay L, Thorens B, Canouil M, Froguel P, Eizirik DL, Cnop M, Marchetti P. Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes. Cell Rep. 2020 Dec 1;33(9):108466. doi: 10.1016/j.celrep.2020.108466. PMID: 33264613
Noseda ACD, Rodrigues LS, Targa ADS, Ilkiw JL, Fagotti J, Dos Santos PD, Cecon E, Markus RP, Solimena M, Jockers R, Lima MMS. MT2 melatonin receptors expressed in the olfactory bulb modulate depressive-like behavior and olfaction in the 6-OHDA model of Parkinson's disease. Eur J Pharmacol. 2021 Jan 15;891:173722. doi: 10.1016/j.ejphar.2020.173722. Epub 2020 Nov 5. PMID: 33159932
Stazi M, Negro S, Megighian A, D'Este G, Solimena M, Jockers R, Lista F, Montecucco C, Rigoni M. Melatonin promotes regeneration of injured motor axons via MT1 receptors. J Pineal Res. 2021 Jan;70(1):e12695. doi: 10.1111/jpi.12695. Epub 2020 Sep 30. PMID: 32939783
Vasiljević J, Torkko JM, Knoch KP, Solimena M. The making of insulin in health and disease. Diabetologia. 2020 Oct;63(10):1981-1989. doi: 10.1007/s00125-020-05192-7. Epub 2020 Sep 7. PMID: 32894308
Pinkert S, Pryshliak M, Pappritz K, Knoch K, Hazini A, Dieringer B, Schaar K, Dong F, Hinze L, Lin J, Lassner D, Klopfleisch R, Solimena M, Tschöpe C, Kaya Z, El-Shafeey M, Beling A, Kurreck J, Van Linthout S, Klingel K, Fechner H. Development of a new mouse model for coxsackievirus-induced myocarditis by attenuating coxsackievirus B3 virulence in the pancreas. Cardiovasc Res. 2020 Aug 1;116(10):1756-1766. doi: 10.1093/cvr/cvz259. PMID: 31598635
Carrat GR, Haythorne E, Tomas A, Haataja L, Müller A, Arvan P, Piunti A, Cheng K, Huang M, Pullen TJ, Georgiadou E, Stylianides T, Amirruddin NS, Salem V, Distaso W, Cakebread A, Heesom KJ, Lewis PA, Hodson DJ, Briant LJ, Fung ACH, Sessions RB, Alpy F, Kong APS, Benke PI, Torta F, Teo AKK, Leclerc I, Solimena M, Wigley DB, Rutter GA. The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis. Mol Metab. 2020 Oct;40:101015. doi: 10.1016/j.molmet.2020.101015. Epub 2020 May 13. PMID: 32416313
Cohrs CM, Panzer JK, Drotar DM, Enos SJ, Kipke N, Chen C, Bozsak R, Schöniger E, Ehehalt F, Distler M, Brennand A, Bornstein SR, Weitz J, Solimena M, Speier S. Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis. Cell Rep. 2020 Apr 7;31(1):107469. doi: 10.1016/j.celrep.2020.03.033. PMID: 32268101
Imam A, Winnebeck EC, Buchholz N, Froguel P, Bonnefond A, Solimena M, Ivanova A, Bouvier M, Plouffe B, Charpentier G, Karamitri A, Jockers R, Roenneberg T, Vetter C. Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study. Front Physiol. 2020 Oct 9;11:564140. doi: 10.3389/fphys.2020.564140. eCollection 2020. PMID: 33162895
Mziaut H, Henniger G, Ganss K, Hempel S, Wolk S, McChord J, Chowdhury K, Ravassard P, Knoch KP, Krautz C, Weitz J, Grützmann R, Pilarsky C, Solimena M, Kersting S. MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling. Mol Metab. 2020 Jan;31:150-162. doi: 10.1016/j.molmet.2019.11.012. Epub 2019 Nov 22.
Pryshliak M, Hazini A, Knoch K, Dieringer B, Tolksdorf B, Solimena M, Kurreck J, Pinkert S, Fechner H. MiR-375-mediated suppression of engineered coxsackievirus B3 in pancreatic cells. FEBS Lett. 2019 Oct 23. doi:10.1002/1873-3468.13647. [Epub ahead of print] PubMed PMID: 31643074.
Pinkert S, Pryshliak M, Pappritz K, Knoch K, Hazini A, Dieringer B, Schaar K, Dong F, Hinze L, Lin J, Lassner D, Klopfleisch R, Solimena M, Tschöpe C, Kaya Z, Beling A, Kurreck J, van Linthout S, Klingel K, Fechner H. Development of a New Mouse Model for Coxsackievirus-Induced Myocarditis by Attenuating Coxsackievirus B3 Virulence in the Pancreas. Cardiovasc Res. 2019 Oct 9. pii: cvz259. doi: 10.1093/cvr/cvz259. [Epub ahead of print] PubMed PMID: 31598635.
Binger KJ, Neukam M, Tattikota SG, Qadri F, Puchkov D, Willmes DM, Wurmsee S, Geisberger S, Dechend R, Raile K, Kurth T, Nguyen G, Poy MN, Solimena M, Muller DN, Birkenfeld AL. Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic beta cells. Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):19983-19988. doi: 10.1073/pnas.1903678116. Epub 2019 Sep 16. PubMed PMID: 31527264; PubMed Central PMCID: PMC6778207.
Barovic M, Distler M, Schöniger E, Radisch N, Aust D, Weitz J, Ibberson M, Schulte AM, Solimena M. Metabolically phenotyped pancreatectomized patients as living donors for the study of islets in health and diabetes. Mol Metab. 2019 Sep;27S:S1-S6. doi: 10.1016/j.molmet.2019.06.006. Review. PubMed PMID: 31500820; PubMed Central PMCID: PMC6768495.
Marchetti P, Schulte AM, Marselli L, Schoniger E, Bugliani M, Kramer W, Overbergh L, Ullrich S, Gloyn AL, Ibberson M, Rutter G, Froguel P, Groop L, McCarthy MI, Dotta F, Scharfmann R, Magnan C, Eizirik DL, Mathieu C, Cnop M, Thorens B, Solimena M. Fostering improved human islet research: a European perspective. Diabetologia. 2019 Aug;62(8):1514-1516. doi: 10.1007/s00125-019-4911-4. Epub 2019 Jun 13. PubMed PMID: 31197398; PubMed Central PMCID: PMC6647243.
Toledo PL, Torkko JM, Müller A, Wegbrod C, Sönmez A, Solimena M, Ermácora MR.
ICA512 RESP18 homology domain is a protein condensing factor and insulin
fibrillation inhibitor. J Biol Chem. 2019 Apr 12. pii: jbc.RA119.007607. doi:
10.1074/jbc.RA119.007607. [Epub ahead of print] PubMed PMID: 30979722.
Khamis A, Canouil M, Siddiq A, Crouch H, Falchi M, Bulow MV, Ehehalt F,
Marselli L, Distler M, Richter D, Weitz J, Bokvist K, Xenarios I, Thorens B,
Schulte AM, Ibberson M, Bonnefond A, Marchetti P, Solimena M, Froguel P. Laser
capture microdissection of human pancreatic islets reveals novel eQTLs associated
with type 2 diabetes. Mol Metab. 2019 Mar 18. pii: S2212-8778(19)30130-9. doi:
10.1016/j.molmet.2019.03.004. [Epub ahead of print] PubMed PMID: 30956117.
Weigert M, Schmidt U, Boothe T, Müller A, Dibrov A, Jain A, Wilhelm B, Schmidt
D, Broaddus C, Culley S, Rocha-Martins M, Segovia-Miranda F, Norden C, Henriques
R, Zerial M, Solimena M, Rink J, Tomancak P, Royer L, Jug F, Myers EW.
Content-aware image restoration: pushing the limits of fluorescence microscopy.
Nat Methods. 2018 Dec;15(12):1090-1097. doi: 10.1038/s41592-018-0216-7. Epub 2018
Nov 26. PubMed PMID: 30478326.
Cecon E, Ivanova A, Luka M, Gbahou F, Friederich A, Guillaume JL, Keller P,
Knoch K, Ahmad R, Delagrange P, Solimena M, Jockers R. Detection of recombinant
and endogenous mouse melatonin receptors by monoclonal antibodies targeting the
C-terminal domain. J Pineal Res. 2019 Mar;66(2):e12540. doi: 10.1111/jpi.12540.
Epub 2019 Jan 17. PubMed PMID: 30475390.
Gerst F, Jaghutriz BA, Staiger H, Schulte AM, Lorza-Gil E, Kaiser G, Panse M,
Haug S, Heni M, Schütz M, Stadion M, Schürmann A, Marzetta F, Ibberson M, Sipos
B, Fend F, Fleming T, Nawroth PP, Königsrainer A, Nadalin S, Wagner S, Peter A,
Fritsche A, Richter D, Solimena M, Häring HU, Ullrich S, Wagner R. The Expression
of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in
Humans. J Clin Endocrinol Metab. 2018 Dec 1;103(12):4373-4383. doi:
10.1210/jc.2018-00791. PubMed PMID: 30202879.
Oshima M, Knoch KP, Diedisheim M, Petzold A, Cattan P, Bugliani M, Marchetti
P, Choudhary P, Huang GC, Bornstein SR, Solimena M, Albagli-Curiel O, Scharfmann
R. Virus-like infection induces human β cell dedifferentiation. JCI Insight. 2018
Feb 8;3(3). pii: 97732. doi: 10.1172/jci.insight.97732. [Epub ahead of print]
PubMed PMID: 29415896; PubMed Central PMCID: PMC5821176.
Monzón-Casanova E, Screen M, Díaz-Muñoz MD, Coulson RMR, Bell SE, Lamers G,
Solimena M, Smith CWJ, Turner M. The RNA-binding protein PTBP1 is necessary for B
cell selection in germinal centers. Nat Immunol. 2018 Mar;19(3):267-278. doi:
10.1038/s41590-017-0035-5. Epub 2018 Jan 22. PubMed PMID: 29358707; PubMed
Central PMCID: PMC5842895.
Carrat, G.R., Hu, M., Nguyen-Tu, M., Chabosseau, P., Gaulton, K.J., van de Bunt, M., Siddiq, A., Falchi, M., Thurner, M., Canouil, M., Pattou, F., Leclerc, I., Pullen, T.J., Cane, M.C., Prabhala, P., Greenwald, W., Schulte, A., Marchetti, P., Ibberson, M., MacDonald, P.E., Fox, J.E.M., Gloyn, A.L., Froguel, P., Solimena, M., McCarthy, M.I., Rutter, G.A. Decreased STARD10 expression is associated with defective insulin secretion in humans and mice. Am. J. Hum. Genet. 100, 238-256 (2017)
Cohrs, C.M., Chen, C., Jahn, S., Stertmann, J., Chmelova, H., Weitz, J., Bähr, A., Klymiuk, N., Steffen, A., Ludwig, B., Kamvissi, V., Wolf, E., Bornstein, S.R., Solimena, M., Speier, S. Vessel network architecture of adult human islets promotes distinct cell-cell interactions in situ and is altered after transplantation. Endocrinology 158, 1-13 (2017)
Ludwig, B., Ludwig, S., Steffen, A., Knauf, Y., Zimerman, B., Heinke, S., Lehmann, S., Schubert, U., Schmid, J., Bleyer, M., Schoenmann, U., Colton, C.K., Bonifacio, E., Solimena, M., Reichel, A., Schally, A.V., Rotem, A., Barkai, U., Grinberg-Rashi, H., Kaup, F., Avni, Y., Jones, P., Bornstein, S.R. Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proc. Natl. Acad. Sci. U.S.A. 114, 11745-11750 (2017)
Müller, A., Neukam, M., Ivanova, A., Sönmez, A., Münster, C., Kretschmar, S., Kalaidzidis, Y., Kurth, T., Verbavatz, J.-M., Solimena, M. A global approach for quantitative super resolution and electron microscopy on cryo and epoxy sections using self-labeling protein tags. Sci. Rep. 7:23 (2017)
Müller, A., Mziaut, H., Neukam, M., Knoch, K.-P., Solimena, M.A 4D view on insulin secretory granule turnover in the β-cell. Diabetes Obes. Metab. 19, 107-114 (2017)
Solimena, M., Schulte, A.M., Marselli, L., Ehehalt, F., Richter, D., Kleeberg, M., Mziaut, H., Knoch, K.-P., Parnis, J., Bugliani, M., Siddiq, A., Jörns, A., Burdet, F., Liechti, R., Suleiman, M., Margerie, D., Syed, F., Distler, M., Grützmann, R., Petretto, E., Moreno-Moral, A., Wegbrod, C., Sönmez, A., Pfriem, K., Friedrich, A., Meinel, J., Wollheim, C.B., Baretton, G.B., Scharfmann, R., Nogoceke, E., Bonifacio, E., Sturm, D., Meyer-Puttlitz, B., Boggi, U., Saeger, H.-D., Filipponi, F., Lesche, M., Meda, P., Dahl, A., Wigger, L., Xenarios, I., Falchi, M., Thorens, B., Weitz, J., Bokvist, K., Lenzen, S., Rutter, G.A., Froguel, P., von Bülow, M., Ibberson, M., Marchetti, P. Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes. Diabetologia, 1-17 (2017)
Anastasiou, V., Ninou, E., Alexopoulou, D., Stertmann, J., Müller, A., Dahl, A., Solimena, M., Speier, S., Serafimidis, I., Gavalas, A. Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice. Diabetologia 59, 139-150 (2016)
Mziaut, H., Mulligan, B., Hoboth, P., Otto, O., Ivanova, A., Herbig, M., Schumann, D., Hildebrandt, T.B., Dehghany, J., Sönmez, A., Münster, C., Meyer-Hermann, M., Guck, J., Kalaidzidis, Y., Solimena, M. The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512. Mol. Metab. 5, 656-68 (2016)
Sosa, L., Torkko, J.M., Primo, M.E., Llovera, R.E., Toledo, P.L., Rios, A.S., Gonzalez Flecha, F.L., Trabucchi, A., Valdez, S.N., Poskus, E., Solimena, M., Ermácora, M.R. Biochemical, biophysical, and functional properties of ICA512/IA-2 RESP18 homology domain. Biochim. Biophys. Acta-Proteins Proteom. 1864, 511-522 (2016)
Benazra, M., Lecomte, M.J., Colace, C., Müller, A., Machado, C., Pechberty, S., Bricout-Neveu, E., Grenier-Godard, M., Solimena, M., Scharfmann, R., Czernichow, P., Ravassard, P. A human beta cell line with drug inducible excision of immortalizing transgenes. Mol. Metab. 4, 916-925 (2015)
Dehghany, J., Hoboth, P., Ivanova, A., Mziaut, H., Müller, A., Kalaidzidis, Y., Solimena, M., Meyer-Hermann, M. A spatial model of insulin-granule dynamics in pancreatic β-cells. Traffic 16, 797-813 (2015)
Ehehalt, F., Sturm, D., Rösler, M., Distler, M., Weitz, J., Kersting, S., Ludwig, B., Schwanebeck, U., Saeger, H.-D., Solimena, M., Grützmann, R. Blood glucose homeostasis in the course of partial pancreatectomy - evidence for surgically reversible diabetes induced by cholestasis. PLoS ONE 10:e0134140 (2015)
Häring, H.-U., Hrabě de Angelis, M., Joost, H.G., Roden, M., Schürmann, A., Solimena, M. 5 Jahre erfolgreiche translationale Forschung - Deutsches Zentrum für Diabetesforschung. Diabetes akt. 13, 58-62 (2015)
Hoboth, P., Müller, A., Ivanova, A., Mziaut, H., Dehghany, J., Sönmez, A., Lachnit, M., Meyer-Hermann, M., Kalaidzidis, Y., Solimena, M. Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies. Proc. Natl. Acad. Sci. U.S.A. 112, E667-E676 (2015)
Noguera, M.E., Primo, M.E., Jakoncic, J., Poskus, E., Solimena, M., Ermácora, M.R. X-ray structure of the mature ectodomain of phogrin. J. Struct. Funct. Genomics 16, 1-9 (2015)
Petzold, A., Solimena, M., Knoch, K.-P. Mechanisms of beta cell dysfunction associated with viral infection. Curr. Diab. Rep. 15:654 (2015)
Sezgin, E., Gutmann, T., Buhl, T., Dirkx, R., Grzybek, M., Coskun, Ü., Solimena, M., Simons, K., Levental, I., Schwille, P. Adaptive lipid packing and bioactivity in membrane domains. PLoS ONE 10:e0123930 (2015)
Torkko, J.M., Primo, M.E., Dirk, R., Friedrich, A., Viehrig, A., Vergari, E., Borgonovo, B., Sönmez, A., Wegbrod, C., Lachnit, M., Münster, C., Sica, M.P., Ermácora, M.R., Solimena, M. Stability of proICA512/IA-2 and its targeting to insulin secretory granules require β4-sheet-mediated dimerization of its ectodomain in the endoplasmic reticulum. Mol. Cell. Biol. 35, 914-927 (2015)
Bornstein, S.R., Amiel, S.A., Rubino, F., Mingrone, G., Kamvissi, V., Solimena, M., Bonifacio, E., Jones, P., Schwarz, P., Birkenfeld, A.L., Behrens, A., Barthel, A., Lechler, R., Peakman, M. Creating a "Transcampus" in diabetes research between King's College London and the Technische Universität Dresden: Update on islet biology and transplantation. Horm. Metab. Res. 47, DOI: 10.1055/s-0034-1396842 (2014)
Knoch, K.P., Nath-Sain, S., Petzold, A., Schneider, H., Beck, M., Wegbrod, C., Sönmez, A., Münster, C., Friedrich, A., Roivainen, M., Solimena, M. PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells. Mol. Metab. 3, 518-530 (2014)
Marciniak, A., Cohrs, C.M., Tsata, V., Chouinard, J.A., Selck, C., Stertmann, J., Reichelt, S., Rose, T., Ehehalt, F., Weitz, J.S., Solimena, M., Slak Rupnik, M., Speier, S. Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology. Nat. Protoc. 9, 2809-2822 (2014)
Ivanova, A., Kalaidzidis, Y., Dirkx, R., Sarov, M., Gerlach, M., Schroth-Diez, B., Müller, A., Liu, Y., Andree, C., Mulligan, B., Münster, C., Kurth, T., Bickle, M., Speier, S., Anastassiadis, K., Solimena, M. Age-dependent labeling and imaging of insulin secretory granules. Diabetes 62, 3687-3696 (2013)
Krautz, C., Wolk, S., Steffen, A., Knoch, K.P., Ceglarek, U., Thiery, J., Bornstein, S., Saeger, H.-D., Solimena, M., Kersting, S. Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets. Diabetologia 56, 1596-1604 (2013)
Ludwig, B., Reichel, A., Steffen, A., Zimerman, B., Schally, A.V., Block, N.L., Colton, C.K., Ludwig, S., Kersting, S., Bonifacio, E., Solimena, M., Gendler, Z., Rotem, A., Barkai, U., Bornstein, S.R. Transplantation of human islets without immunosuppression. Proc. Natl. Acad. Sci. U.S.A. 110, 19054-19058 (2013)
Magro, M.G., Solimena, M. Regulation of β-cell function by RNA-binding proteins. Mol. Metab. 2, 348-355 (2013)
Phieler, J., Chung, K.-J., Chatzigeorgiou, A., Klotzsche-von Ameln, A., Garcia-Martin, R., Sprott, D., Moisidou, M., Tzanavari, T., Ludwig, B., Baraban, E., Ehrhart-Bornstein, M., Bornstein, S.R., Mziaut, H., Solimena, M., Karalis, K.P., Economopoulou, M., Lambris, J.D., Chavakis, T. The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance. J. Immunol. 191, 4367-4374 (2013)
Sturm, D., Marselli, L., Ehehalt, F., Richter, D., Distler, M., Kersting, S., Grützmann, R., Bokvist, K., Froguel, P., Liechti, R., Jörns, A., Meda, P., Baretton, G.B., Saeger, H.-D., Schulte, A.M., Marchetti, P., Solimena, M. Improved protocol for laser microdissection of human pancreatic islets from surgical specimens. J. Vis. Exp. 71:e50231 (2013)
Bonner, S.M., Pietropaolo, S.L., Fan, Y.M., Chang, Y., Sethupathy, P., Morran, M.P., Beems, M., Giannoukakis, N., Trucco, G., Palumbo, M.O., Solimena, M., Pugliese, A., Polychronakos, C., Trucco, M., Pietropaolo, M. Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression. J. Biol. Chem. 287, 17882-17893 (2012)
Dirkx, R., Solimena, M. Cholesterol-enriched membrane rafts and insulin secretion. J. Diab. Invest. 3, 339-346 (2012)
Fava, E., Dehghany, J., Ouwendijk, J., Müller, A., Niederlein, A., Verkade, P., Meyer-Hermann, M., Solimena, M. Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling. Diabetologia 55, 1013-1023 (2012)
Häring, H.-U., Hrabě de Angelis, M., Joost, H.-G., Roden, M., Solimena, M. Forschen für eine Zukunft ohne Diabetes - Deutsches Zentrum für Diabetesforschung. Diabetes akt. 10, 106-110 (2012)
Heni, M., Ketterer, C., Wagner, R., Linder, K., Böhm, A., Herzberg-Schäfer, S.A., Machicao, F., Knoch, K.P., Fritsche, A., Staiger, H., Häring, H.-U., Solimena, M. Polymorphism rs11085226 in the gene encoding polypyrimidine tract-binding protein 1 negatively affects glucose-stimulated insulin secretion. PLoS ONE 7:e46154 (2012)
Bötticher, G., Sturm, D., Ehehalt, F., Knoch, K.P., Kersting, S., Grützmann, R., Baretton, G.B., Solimena, M., Saeger, H.-D. Isolation of human islets from partially pancreatectomized patients. J. Vis. Exp. 53:e2962 (2011)
Geis, C., Weishaupt, A., Grünewald, B., Wultsch, T., Reif, A., Gerlach, M., Dirkx, R., Solimena, M., Perani, D., Heckmann, M., Toyka, K.V., Folli, F., Sommer, C. Human stiff-person syndrome IgG induces anxious behavior in rats. PLoS ONE 6:e16775 (2011)
Primo, M.E., Jakoncic, J., Noguera, M.E., Risso, V.A., Sosa, L., Sica, M.P., Solimena, M., Poskus, E., Ermácora, M.R. Protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase ICA512 ectodomain. PLoS ONE 6:e24191 (2011)
Steffen, A., Ludwig, B., Krautz, C., Bornstein, S., Solimena, M. Functional assessment of automatically sorted pancreatic islets using large particle flow cytometry. Islets 3, 267-270 (2011)
Suckale, J., Wendling, O., Masjkur, J., Jäger, M., Münster, C., Anastassiadis, K., Stewart, A.F., Solimena, M. PTBP1 is required for embryonic development before gastrulation. PLoS ONE 6:e16992 (2011)
Ehehalt, F., Knoch, K.P., Erdmann, K., Krautz, C., Jäger, M., Steffen, A., Wegbrod, C., Meisterfeld, R., Kersting, S., Bergert, H., Kuhlisch, E., Bornstein, S., Bonifacio, E., Saeger, H.-D., Solimena, M. Impaired insulin turnover in islets from type 2 diabetic patients. Islets 2, 30-36 (2010)
Liu, Y., Suckale, J., Masjkur, J., Magro, M.G., Steffen, A., Anastassiadis, K., Solimena, M. Tamoxifen-independent recombination in the RIP-CreER mouse. PLoS ONE 5:e13533 (2010)
Ries, J., Bayer, M., Csúcs, G., Dirkx, R., Solimena, M., Ewers, H., Schwille, P. Automated suppression of sample-related artifacts in Fluorescence Correlation Spectroscopy. Opt. Express. 18, 11073-11082 (2010)
Schubert, S., Knoch, K.P., Ouwendijk, J., Mohammed, S., Bodrov, Y., Jäger, M., Altkrüger, A., Wegbrod, C., Adams, M.E., Kim, Y., Froehner, S.C., Jensen, O.N., Kalaidzidis, Y., Solimena, M. β2-Syntrophin is a Cdk5 substrate that restrains the motility of insulin secretory granules. PLoS ONE 5:e12929 (2010)
Solimena, M., Speier, S. Insulin release: Shedding light on a complex matter. Cell Metab. 12, 5-6 (2010)
Suckale, J., Solimena, M. The insulin secretory granule as a signaling hub. Trends Endocrinol. Metab. 21, 599-609 (2010)
Liu, Y., Mziaut, H., Ivanova, A., Solimena, M. beta-Cells at the crossroads: Choosing between insulin granule production and proliferation. Diabetes Obes. Metab. 11, 54-64 (2009)
Reimann, M., Bonifacio, E., Solimena, M., Schwarz, P.E., Ludwig, B., Hanefeld, M., Bornstein, S.R. An update on preventive and regenerative therapies in diabetes mellitus. Pharmacol. Ther. 121, 317-331 (2009)
Süss, C., Czupalla, C., Winter, C., Pursche, T., Knoch, K.P., Schroeder, M., Hoflack, B., Solimena, M. Rapid changes of mRNA-binding protein levels following glucose and 3-isobutyl-1-methylxanthine stimulation of insulinoma INS-1 cells. Mol. Cell. Proteomics 8, 393-408 (2009)