Publikationen

Carrat, G.R., Hu, M., Nguyen-Tu, M., Chabosseau, P., Gaulton, K.J., van de Bunt, M., Siddiq, A., Falchi, M., Thurner, M., Canouil, M., Pattou, F., Leclerc, I., Pullen, T.J., Cane, M.C., Prabhala, P., Greenwald, W., Schulte, A., Marchetti, P., Ibberson, M., MacDonald, P.E., Fox, J.E.M., Gloyn, A.L., Froguel, P., Solimena, M., McCarthy, M.I., Rutter, G.A. Decreased STARD10 expression is associated with defective insulin secretion in humans and mice. Am. J. Hum. Genet. 100, 238-256 (2017)

Cohrs, C.M., Chen, C., Jahn, S., Stertmann, J., Chmelova, H., Weitz, J., Bähr, A., Klymiuk, N., Steffen, A., Ludwig, B., Kamvissi, V., Wolf, E., Bornstein, S.R., Solimena, M., Speier, S. Vessel network architecture of adult human islets promotes distinct cell-cell interactions in situ and is altered after transplantation. Endocrinology 158, 1-13 (2017)

Ludwig, B., Ludwig, S., Steffen, A., Knauf, Y., Zimerman, B., Heinke, S., Lehmann, S., Schubert, U., Schmid, J., Bleyer, M., Schoenmann, U., Colton, C.K., Bonifacio, E., Solimena, M., Reichel, A., Schally, A.V., Rotem, A., Barkai, U., Grinberg-Rashi, H., Kaup, F., Avni, Y., Jones, P., Bornstein, S.R. Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proc. Natl. Acad. Sci. U.S.A. 114, 11745-11750 (2017)

Müller, A., Neukam, M., Ivanova, A., Sönmez, A., Münster, C., Kretschmar, S., Kalaidzidis, Y., Kurth, T., Verbavatz, J.-M., Solimena, M. A global approach for quantitative super resolution and electron microscopy on cryo and epoxy sections using self-labeling protein tags. Sci. Rep. 7:23 (2017)

Müller, A., Mziaut, H., Neukam, M., Knoch, K.-P., Solimena, M.A 4D view on insulin secretory granule turnover in the β-cell. Diabetes Obes. Metab. 19, 107-114 (2017)

Solimena, M., Schulte, A.M., Marselli, L., Ehehalt, F., Richter, D., Kleeberg, M., Mziaut, H., Knoch, K.-P., Parnis, J., Bugliani, M., Siddiq, A., Jörns, A., Burdet, F., Liechti, R., Suleiman, M., Margerie, D., Syed, F., Distler, M., Grützmann, R., Petretto, E., Moreno-Moral, A., Wegbrod, C., Sönmez, A., Pfriem, K., Friedrich, A., Meinel, J., Wollheim, C.B., Baretton, G.B., Scharfmann, R., Nogoceke, E., Bonifacio, E., Sturm, D., Meyer-Puttlitz, B., Boggi, U., Saeger, H.-D., Filipponi, F., Lesche, M., Meda, P., Dahl, A., Wigger, L., Xenarios, I., Falchi, M., Thorens, B., Weitz, J., Bokvist, K., Lenzen, S., Rutter, G.A., Froguel, P., von Bülow, M., Ibberson, M., Marchetti, P. Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes. Diabetologia, 1-17 (2017)

Anastasiou, V., Ninou, E., Alexopoulou, D., Stertmann, J., Müller, A., Dahl, A., Solimena, M., Speier, S., Serafimidis, I., Gavalas, A. Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice. Diabetologia 59, 139-150 (2016)

Mziaut, H., Mulligan, B., Hoboth, P., Otto, O., Ivanova, A., Herbig, M., Schumann, D., Hildebrandt, T.B., Dehghany, J., Sönmez, A., Münster, C., Meyer-Hermann, M., Guck, J., Kalaidzidis, Y., Solimena, M. The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512. Mol. Metab. 5, 656-68 (2016)

Sosa, L., Torkko, J.M., Primo, M.E., Llovera, R.E., Toledo, P.L., Rios, A.S., Gonzalez Flecha, F.L., Trabucchi, A., Valdez, S.N., Poskus, E., Solimena, M., Ermácora, M.R. Biochemical, biophysical, and functional properties of ICA512/IA-2 RESP18 homology domain. Biochim. Biophys. Acta-Proteins Proteom. 1864, 511-522 (2016)

Benazra, M., Lecomte, M.J., Colace, C., Müller, A., Machado, C., Pechberty, S., Bricout-Neveu, E., Grenier-Godard, M., Solimena, M., Scharfmann, R., Czernichow, P., Ravassard, P. A human beta cell line with drug inducible excision of immortalizing transgenes. Mol. Metab. 4, 916-925 (2015)

Dehghany, J., Hoboth, P., Ivanova, A., Mziaut, H., Müller, A., Kalaidzidis, Y., Solimena, M., Meyer-Hermann, M. A spatial model of insulin-granule dynamics in pancreatic β-cells. Traffic 16, 797-813 (2015)

Ehehalt, F., Sturm, D., Rösler, M., Distler, M., Weitz, J., Kersting, S., Ludwig, B., Schwanebeck, U., Saeger, H.-D., Solimena, M., Grützmann, R. Blood glucose homeostasis in the course of partial pancreatectomy - evidence for surgically reversible diabetes induced by cholestasis. PLoS ONE 10:e0134140 (2015)

Häring, H.-U., Hrabě de Angelis, M., Joost, H.G., Roden, M., Schürmann, A., Solimena, M. 5 Jahre erfolgreiche translationale Forschung - Deutsches Zentrum für Diabetesforschung. Diabetes akt. 13, 58-62 (2015)

Hoboth, P., Müller, A., Ivanova, A., Mziaut, H., Dehghany, J., Sönmez, A., Lachnit, M., Meyer-Hermann, M., Kalaidzidis, Y., Solimena, M. Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies. Proc. Natl. Acad. Sci. U.S.A. 112, E667-E676 (2015)

Noguera, M.E., Primo, M.E., Jakoncic, J., Poskus, E., Solimena, M., Ermácora, M.R. X-ray structure of the mature ectodomain of phogrin. J. Struct. Funct. Genomics 16, 1-9 (2015)

Petzold, A., Solimena, M., Knoch, K.-P. Mechanisms of beta cell dysfunction associated with viral infection. Curr. Diab. Rep. 15:654 (2015)

Sezgin, E., Gutmann, T., Buhl, T., Dirkx, R., Grzybek, M., Coskun, Ü., Solimena, M., Simons, K., Levental, I., Schwille, P. Adaptive lipid packing and bioactivity in membrane domains. PLoS ONE 10:e0123930 (2015)

Torkko, J.M., Primo, M.E., Dirk, R., Friedrich, A., Viehrig, A., Vergari, E., Borgonovo, B., Sönmez, A., Wegbrod, C., Lachnit, M., Münster, C., Sica, M.P., Ermácora, M.R., Solimena, M. Stability of proICA512/IA-2 and its targeting to insulin secretory granules require β4-sheet-mediated dimerization of its ectodomain in the endoplasmic reticulum.  Mol. Cell. Biol. 35, 914-927 (2015)

Bornstein, S.R., Amiel, S.A., Rubino, F., Mingrone, G., Kamvissi, V., Solimena, M., Bonifacio, E., Jones, P., Schwarz, P., Birkenfeld, A.L., Behrens, A., Barthel, A., Lechler, R., Peakman, M. Creating a "Transcampus" in diabetes research between King's College London and the Technische Universität Dresden: Update on islet biology and transplantation. Horm. Metab. Res. 47, DOI: 10.1055/s-0034-1396842 (2014)

Knoch, K.P., Nath-Sain, S., Petzold, A., Schneider, H., Beck, M., Wegbrod, C., Sönmez, A., Münster, C., Friedrich, A., Roivainen, M., Solimena, M. PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells. Mol. Metab. 3, 518-530 (2014)

Marciniak, A., Cohrs, C.M., Tsata, V., Chouinard, J.A., Selck, C., Stertmann, J., Reichelt, S., Rose, T., Ehehalt, F., Weitz, J.S., Solimena, M., Slak Rupnik, M., Speier, S. Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology. Nat. Protoc. 9, 2809-2822 (2014)

Ivanova, A., Kalaidzidis, Y., Dirkx, R., Sarov, M., Gerlach, M., Schroth-Diez, B., Müller, A., Liu, Y., Andree, C., Mulligan, B., Münster, C., Kurth, T., Bickle, M., Speier, S., Anastassiadis, K., Solimena, M. Age-dependent labeling and imaging of insulin secretory granules. Diabetes 62, 3687-3696 (2013)

Krautz, C., Wolk, S., Steffen, A., Knoch, K.P., Ceglarek, U., Thiery, J., Bornstein, S., Saeger, H.-D., Solimena, M., Kersting, S. Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets. Diabetologia 56, 1596-1604 (2013)

Ludwig, B., Reichel, A., Steffen, A., Zimerman, B., Schally, A.V., Block, N.L., Colton, C.K., Ludwig, S., Kersting, S., Bonifacio, E., Solimena, M., Gendler, Z., Rotem, A., Barkai, U., Bornstein, S.R. Transplantation of human islets without immunosuppression. Proc. Natl. Acad. Sci. U.S.A. 110, 19054-19058 (2013)

Magro, M.G., Solimena, M.  Regulation of β-cell function by RNA-binding proteins. Mol. Metab. 2, 348-355 (2013)

Phieler, J., Chung, K.-J., Chatzigeorgiou, A., Klotzsche-von Ameln, A., Garcia-Martin, R., Sprott, D., Moisidou, M., Tzanavari, T., Ludwig, B., Baraban, E., Ehrhart-Bornstein, M., Bornstein, S.R., Mziaut, H., Solimena, M., Karalis, K.P., Economopoulou, M., Lambris, J.D., Chavakis, T. The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance. J. Immunol. 191, 4367-4374 (2013)

Sturm, D., Marselli, L., Ehehalt, F., Richter, D., Distler, M., Kersting, S., Grützmann, R., Bokvist, K., Froguel, P., Liechti, R., Jörns, A., Meda, P., Baretton, G.B., Saeger, H.-D., Schulte, A.M., Marchetti, P., Solimena, M. Improved protocol for laser microdissection of human pancreatic islets from surgical specimens.  J. Vis. Exp. 71:e50231 (2013)

Bonner, S.M., Pietropaolo, S.L., Fan, Y.M., Chang, Y., Sethupathy, P., Morran, M.P., Beems, M., Giannoukakis, N., Trucco, G., Palumbo, M.O., Solimena, M., Pugliese, A., Polychronakos, C., Trucco, M., Pietropaolo, M. Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression. J. Biol. Chem. 287, 17882-17893 (2012)

Dirkx, R., Solimena, M. Cholesterol-enriched membrane rafts and insulin secretion. J. Diab. Invest. 3, 339-346 (2012)

Fava, E., Dehghany, J., Ouwendijk, J., Müller, A., Niederlein, A., Verkade, P., Meyer-Hermann, M., Solimena, M. Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling. Diabetologia 55, 1013-1023 (2012)

Häring, H.-U., Hrabě de Angelis, M., Joost, H.-G., Roden, M., Solimena, M. Forschen für eine Zukunft ohne Diabetes - Deutsches Zentrum für Diabetesforschung. Diabetes akt. 10, 106-110 (2012)

Heni, M., Ketterer, C., Wagner, R., Linder, K., Böhm, A., Herzberg-Schäfer, S.A., Machicao, F., Knoch, K.P., Fritsche, A., Staiger, H., Häring, H.-U., Solimena, M. Polymorphism rs11085226 in the gene encoding polypyrimidine tract-binding protein 1 negatively affects glucose-stimulated insulin secretion. PLoS ONE 7:e46154 (2012)

Bötticher, G., Sturm, D., Ehehalt, F., Knoch, K.P., Kersting, S., Grützmann, R., Baretton, G.B., Solimena, M., Saeger, H.-D. Isolation of human islets from partially pancreatectomized patients.  J. Vis. Exp. 53:e2962 (2011)

Geis, C., Weishaupt, A., Grünewald, B., Wultsch, T., Reif, A., Gerlach, M., Dirkx, R., Solimena, M., Perani, D., Heckmann, M., Toyka, K.V., Folli, F., Sommer, C. Human stiff-person syndrome IgG induces anxious behavior in rats. PLoS ONE 6:e16775 (2011)

Primo, M.E., Jakoncic, J., Noguera, M.E., Risso, V.A., Sosa, L., Sica, M.P., Solimena, M., Poskus, E., Ermácora, M.R. Protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase ICA512 ectodomain. PLoS ONE 6:e24191 (2011)

Steffen, A., Ludwig, B., Krautz, C., Bornstein, S., Solimena, M. Functional assessment of automatically sorted pancreatic islets using large particle flow cytometry. Islets 3, 267-270 (2011)

Suckale, J., Wendling, O., Masjkur, J., Jäger, M., Münster, C., Anastassiadis, K., Stewart, A.F., Solimena, M. PTBP1 is required for embryonic development before gastrulation. PLoS ONE 6:e16992 (2011)

Ehehalt, F., Knoch, K.P., Erdmann, K., Krautz, C., Jäger, M., Steffen, A., Wegbrod, C., Meisterfeld, R., Kersting, S., Bergert, H., Kuhlisch, E., Bornstein, S., Bonifacio, E., Saeger, H.-D., Solimena, M. Impaired insulin turnover in islets from type 2 diabetic patients. Islets 2, 30-36 (2010)

Liu, Y., Suckale, J., Masjkur, J., Magro, M.G., Steffen, A., Anastassiadis, K., Solimena, M. Tamoxifen-independent recombination in the RIP-CreER mouse. PLoS ONE 5:e13533 (2010)

Ries, J., Bayer, M., Csúcs, G., Dirkx, R., Solimena, M., Ewers, H., Schwille, P. Automated suppression of sample-related artifacts in Fluorescence Correlation Spectroscopy. Opt. Express. 18, 11073-11082 (2010)

Schubert, S., Knoch, K.P., Ouwendijk, J., Mohammed, S., Bodrov, Y., Jäger, M., Altkrüger, A., Wegbrod, C., Adams, M.E., Kim, Y., Froehner, S.C., Jensen, O.N., Kalaidzidis, Y., Solimena, M. β2-Syntrophin is a Cdk5 substrate that restrains the motility of insulin secretory granules. PLoS ONE 5:e12929 (2010)

Solimena, M., Speier, S. Insulin release: Shedding light on a complex matter. Cell Metab. 12, 5-6 (2010)

Suckale, J., Solimena, M. The insulin secretory granule as a signaling hub. Trends Endocrinol. Metab. 21, 599-609 (2010)

Liu, Y., Mziaut, H., Ivanova, A., Solimena, M. beta-Cells at the crossroads: Choosing between insulin granule production and proliferation. Diabetes Obes. Metab. 11, 54-64 (2009)

Reimann, M., Bonifacio, E., Solimena, M., Schwarz, P.E., Ludwig, B., Hanefeld, M., Bornstein, S.R. An update on preventive and regenerative therapies in diabetes mellitus. Pharmacol. Ther. 121, 317-331 (2009)

Süss, C., Czupalla, C., Winter, C., Pursche, T., Knoch, K.P., Schroeder, M., Hoflack, B., Solimena, M. Rapid changes of mRNA-binding protein levels following glucose and 3-isobutyl-1-methylxanthine stimulation of insulinoma INS-1 cells. Mol. Cell. Proteomics 8, 393-408 (2009)

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Dana Krüger
Letzte Änderung: 22.01.2018