DNA damage response
The field of DNA damage response is increasingly moving into a genome-wide perspective, since it becomes clear that the respose to DNA damage can be very different, dependent on where the damage is happening and at which time of the cell cycle. We address these topics largely in collaboration, e.g. to study the role of RTEL1 in regulating G4/R-loops in collaboration with the Boulton lab, and the role of AHNAK in regulating the p53 response with the Soutoglou lab.
We also study double strand breaks and the associated DNA damage response in meiosis with the International Network of Ovarian Biology, a new consortium that focusses on investigating the molecular mechanisms of genetic quality control, DNA damage and repair in oocytes.