Project A02
The impact of hypoxia pathway proteins on the adrenergic response in the adrenal gland and beyond
During the second funding period we will continue our research related to the impact of hypoxia-pathway proteins (HPPs) in the HPA axis and sympathetic and adrenal medullary systems. Based on our unique collection of adrenal gland-specific HPP transgenic mouse lines we aim to further delineate the consequences of chronically altered steroidogenesis and modified responses of chromaffin cells due to changes in the PHD-HIFα axis. Addressing these complex interplays requires merging expertise in haematopoiesis, hypoxia pathways, adrenergic signalling and the adrenal gland; this will be brought together by the Wielockx group (Hypoxia-pathway proteins/ haematopoiesis/ inflammatory models), the El-Armouche group (SNS/ beta-adrenergic signalling) and the close collaborations established with a number of other groups
Aims
(I) Determine the impact of chronic exposure to systemic high/low glucocorticoid levels in adrenocortical-related HPP transgenic mice during haematopoiesis/erythropoiesis and local immune response.
(II) Characterise the consequences of modulating central HPPs in chromaffin cells in mice.
(III) Define the potential role of β2AR on haematopoietic cell lineages during (stress) haematopoiesis/erythropoiesis.
| Principal Investigators | Institution |
| Prof. Dr. med. Ali El-Armouche | TUD |
| Prof. Dr. Ben Wielockx, PhD | TUD |
Prof. Dr. med. Ali El-Armouche (left) und Prof. Dr. Ben Wielockx, PhD (right)