Project S01
Analytical Platform
Project S01 provides centralized highly sophisticated analytical tools, which are crucial in the context of adrenal research due to the need of accurate measurements of adrenal hormones, such as catecholamine metabolites and steroids. Besides liquid chromatography – tandem mass spectrometry (LC-MS/MS) based methodologies for targeted quantitative metabolite profiling and untargeted metabolomics, further screening platforms using high-resolution mass spectrometry, such as MALDI-mass spectrometry imaging in the context of tissue-based research, for biomarker discovery etc., are available. All those mass spectrometry based methodologies provide a powerful tool to uncover changes in metabolism associated with adrenal diseases.
Aims
(I) Provide state-of-the-art analytical methods for sensitive and targeted analyses of different panels of compounds including flux analysis and untargeted metabolomics/steroidomics approaches.
(II) Improve and develop methodologies for targeted quantitative LC-MS/MS analysis and untargeted metabolomics.
(III) Harmonise methods with other institutions and translate precise and accurate research-based analytical tools into routine clinical applications.
| Principal Investigators | Institution |
| Dr. rer. nat. Mirko Peitzsch | TUD |
| Prof. Dr. Axel Walch | HMGU |
| Dr. rer. nat. Max Kurlbaum | JMU |
| Dr. med. Martin Bidlingmaier | LMU |
| Dr. Tiago C. Alves | TUD |
