Project B15
Primary aldosteronism: pathogenesis and advanced approaches for subtyping
Project B15 is about primary aldosteronism which is characterized by excessive secretion of aldosterone mainly due to an unilateral adenoma (APA) or bilateral adrenal hyperplasia (BAH). Since the pathogenesis of BAH remains obscure, this project will define pathogenetic mechanisms causing BAH by delineating the molecular histopathological differences between normal adrenals, BAH and APA. In addition, this project will establish new diagnostic markers (venous steroid profiling) for primary aldosteronism and for stratification of the subtypes APA and BAH.
Aims
(I) Identify molecular determinants of the pathogenesis of bilateral adrenal hyperplasia (BAH).
(II) Establish a peripheral venous steroid signature that classifies primary aldosteronism genotype and identify an association between steroid profiling and molecular morphology.
(III) Prospectively validate peripheral venous steroid biomarker panels for the diagnosis and differentiation of unilateral aldosterone-producing adenoma (APA) and BAH.
| Principal Investigators | Institution |
| Prof. Dr. Graeme Eisenhofer | TUD |
| Tracy Ann Williams, PhD | LMU |
