Glauche Lab: Theoretical Stem Cell Biology
Stem cells are fascinating cells as they retain the potential to differentiate into distinct, functional cell types while at the same time maintaining their own population. As such, stem cells are the building blocks of development and sustained tissue function, and did also become the primary target for many cell based therapies. However, many regulating principles on the cellular and on the subcellular level are still not fully understood.
The Glauche Lab focuses on conceptual and quantitative aspects of stem cell regulation with a strong emphasis on hematopoietic stem cells. We are using differential equation models and agent-based modeling approaches to understand the organizational principles underlying the robust population behavior of these cells including aspects of clonal heterogeneity, regulation of stem cell turnover, stem cell exhaustion and aging, spatial organization, and feedback mechanisms. Our work extends towards models of disease pathogenesis and treatment in myeloid leukemia, but also looks at other stem cell systems such as embryonic or epithelial stem cells.
Research areas
- Chronic and acute myeloid leukemia
- Clonal competition phenomena
- Cell fate regulation of mouse embryonic stem cells
- Modelling of the ageing haematopoiesis
- Natural competition and clonality of stem cells
- Proliferation- and differentiation control of haematopoietic stem cells
- Stem cell-niche interaction
Projects
current projects:
- MEDiC —Modellstudiengang Medizin (Bund, Freistaat Sachsen)
finished projects (selection):
- CHOICE — Characterization of the osteo-hematopoietic niche during malignant evolution (DKTK)
- PrediCt — Mathematical modelling of TKI effects and immune response to predict patient-specific treatment dynamics in CML (BMBF, EU)
-
MessAge — Medical systems biology of ageing haematopoiesis: clonality, age-associated alterations, and related diseases (BMBF, e:Bio)
- HaematoOPT — Model-based optimization and individualization of treatment strategies in hematology (BMBF, e:Med Demonstratoren)
- Clonality of hematopoietic reconstitution: old versus young grafts in elderly recipients - lessons from mouse (Jackstaedt Stiftung)
- Modeling the reconstitution dynamics of hematopoiesis after stem cell transplantation using neutral multicolor barcode marking for high-resolution cell tracking (DFG)
- Molecular and Spatial Organization of mESCs (DFG)
Group Leader
© Ingmar Glauche
Group leader
NameMr PD Dr. rer. med. Ingmar Glauche
Deputy Institute Director
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Members of the research group
© Christoph Baldow
Ph.D. student
NameMr Dipl.-Inf. Christoph Baldow
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© Andrea Gottschalk
Ph.D. student
NameMs Dipl.-Biomath. (FH) Andrea Gottschalk
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© Markus Klose
Ph.D. student
NameMr Dipl.-Math. Markus Klose
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© Lars Thielecke
Research fellow (external: DKTK)
NameMr Dipl.-Inf. Lars Thielecke
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© Friedemann Uschner
Research fellow
NameMr Dr. rer. nat. Friedemann Uschner
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Ph.D. student
NameMr Sebastian Wagner
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© Thomas Zerjatke
Ph.D. student
NameMr Dipl.-Biomath. Thomas Zerjatke
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Students (MD/ Ph.D. students, student assistants)
MD student
NameMs Elena Karg
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Former staff members
Guest scientist
NameMr Artur Cesar Fassoni Ph.D.
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© Maksim Zhdanov
Student assistant
NameMr Maksim Zhdanov B.Sc.
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© Helene Hoffmann
Ph.D. student
NameMs Helene Hoffmann M.Sc.
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© Tom Hähnel
MD student
NameMr Tom Hähnel
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© Jonas Schadt
MD student
NameMr Jonas Schadt
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