Modeling of antimicrobial resistance (AMR) based on surveillance data of acute care hospitals in Saxony

The application of antibiotics promotes the selection and evolution of drug-resistant bacteria that can in turn spread resistance, thereby even exceeding species boundaries. As a consequence, vitally important substances to treat severe diseases caused by pathogens become ineffective and thus cannot be utilised any more. At the same time, we observe a shortage of novel drugs in development that could potentially bypass or eliminate resistances. This has led to multi-drug resistant bacteria like the Methicillin-resistant Staph. aureus(MRSA), which is distributed worldwide and shows higher morbidity and lethality compared to the wild-type. A consecutive surveillance and analysis of both comprehensive antimicrobial consumption and multi-drug resistance data depicts a crucial step for a better understanding of the relation between the two. In doing so, the influence of the particularised consumption on resistance behaviour will be evaluated by mathematical and statistical modelling. The project is a cooperation of the IMB with the department of infectious diseases of University Hospital Carl Gustav Carus involved with an external partner at Ruhr-Universität Bochum.

Coordinator

• Dr Dr Katja de With (department of infectious diseases, University Hospital Carl Gustav Carus)

Involved scientists

• Prof. Dr. Ingo Roeder 
• Michael Rank 

Coorperationa

• Dr. Dr. Katja de With (Zentralbereich Klinische Infektiologie, UKD)
• Anna Kather (Zentralbereich Klinische Infektiologie, UKD)
• Dr. Hans H. Diebner (Ruhr-Universität Bochum)

Publications

Funding

Sächsisches Staatsministerium für Soziales und Gesellschaftlichen Zusammenhalt (SMS) - grant to department of infectious diseases, University Hospital Carl Gustav Carus