BMBF e:Bio MessAge "Medical systems biology of ageing haematopoiesis: clonality, age-associated alterations, and related diseases"
The steadily increasing life expectancy poses severe challenges to the health care system in developed countries. Age-associated diseases and increasing tumour incidence often result in extensive and long-term medical care of elderly people. Although a naïve understanding of “ageing” is present to everyone, the precise mechanisms of the underlying processes are not yet fully understood. Our research focuses on a systemic and model-based understanding of ageing haematopoiesis with a particular focus on the investigation of various aspects of ageing-related decline of stem cell function in physiological and diseased situations. The resulting, quantitative models contribute to a comprehensive, systemic perception of haematopoietic stem cells and their ageing-related alterations, which is ultimately necessary to understand and to control clonal dynamics in a large variety of haematopoietic stem cell related therapies.
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Funding
BMBF (031A315) funded within the Innovationswettbewerb Systembiologie